Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome.
Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome.
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DOI：
10.1016/j.nicl.2018.03.008
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Butler C
中科院分区：
文献类型：
--
作者：
Ahmed S;Irish M;Loane C;Baker I;Husain M;Thompson S;Blanco-Duque C;Mackay C;Zamboni G;Foxe D;Hodges JR;Piguet O;Butler C
后皮质萎缩是一种神经退行性综合征，其特征是视觉和感知处理的进行性破坏，与顶枕皮质萎缩相关。目前的诊断标准描述情节记忆功能的相对保留，但最近的研究结果表明，顺行记忆往往受损。这些缺陷是否延伸到远程记忆还没有得到解决。大量的证据表明，对遥远过去的自传体事件的回忆与视觉图像的成功检索相一致。我们假设后皮质萎缩的视觉处理缺陷会导致自传体记忆提取受损。14名后皮质萎缩患者、18名典型阿尔茨海默病患者和28名健康对照者完成了自传体访谈。自传体记忆在后皮质萎缩的特点是一个显着的损失，内部，情节细节相对于控制和相同程度的典型阿尔茨海默氏病患者，在与外部细节增加切线的记忆描述。后皮质萎缩患者的记忆叙述显示时空和感知细节的特定减少。基于体素的形态学分析显示，与典型阿尔茨海默病的内侧颞叶特征性萎缩相比，后皮质萎缩的顶枕皮质萎缩，但双侧大脑半球相对较少。对表现出后皮质萎缩特异性萎缩的大脑区域进行分析，发现自传体记忆中的知觉细节与右侧楔前叶的灰质密度之间存在相关性。这项研究表明，尽管相对保留内侧颞叶结构的后皮质萎缩的远程记忆障碍。结果表明，第一次，深刻的自传体记忆障碍的PCA，并表明这是由公认的赤字高阶视觉处理。研究结果进行了讨论的背景下，后顶叶的图像和记忆的贡献，自传体记忆障碍的诊断和管理协议在后皮质萎缩的临床意义。PCA中的自传体记忆显示出内部的、情节细节的显著丢失。叙述显示了具体的减少时空和感知细节。感知细节的丢失与右侧楔前叶的灰质密度相关。自传体记忆受损是由高阶视觉处理缺陷驱动的。
Posterior cortical atrophy is a neurodegenerative syndrome characterised by progressive disruption of visual and perceptual processing, associated with atrophy in the parieto-occipital cortex. Current diagnostic criteria describe relative sparing of episodic memory function, but recent findings suggest that anterograde memory is often impaired. Whether these deficits extend to remote memory has not been addressed. A large body of evidence suggests that the recollection of an autobiographical event from the remote past coincides with the successful retrieval of visual images. We hypothesised that the profound visual processing deficits in posterior cortical atrophy would result in impaired autobiographical memory retrieval. Fourteen posterior cortical atrophy patients, eighteen typical Alzheimer's disease patients and twenty-eight healthy controls completed the Autobiographical Interview. Autobiographical memory in posterior cortical atrophy was characterised by a striking loss of internal, episodic detail relative to controls and to same extent as typical Alzheimer's disease patients, in conjunction with an increase in external details tangential to the memory described. The memory narratives of posterior cortical atrophy patients showed a specific reduction in spatiotemporal and perceptual detail. Voxel-based morphometry analysis revealed atrophy of the parieto-occipital cortices in posterior cortical atrophy but relatively spared hippocampi bilaterally, compared with characteristic atrophy of the medial temporal lobes in typical Alzheimer's disease. Analysis of brain regions showing posterior cortical atrophy-specific atrophy revealed a correlation between perceptual details in autobiographical memory and grey matter density in the right precuneus. This study demonstrates remote memory impairment in posterior cortical atrophy despite relatively preserved medial temporal lobe structures. The results demonstrate, for the first time, profound autobiographical memory impairment in PCA and suggest that this is driven by the well-recognised deficits in higher-order visual processing. The findings are discussed in the context of posterior parietal contributions to imagery and memory, and the clinical implications of autobiographical memory impairment for diagnostic and management protocols in posterior cortical atrophy. Autobiographical memory in PCA shows a striking loss of internal, episodic detail. Narratives showed a specific reduction in spatiotemporal and perceptual detail. Loss of perceptual details correlated with grey matter density in the right precuneus. Impaired autobiographical memory is driven by deficient higher-order visual processing.
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影响因子：
2.9
作者：
Dhindsa K;Drobinin V;King J;Hall GB;Burgess N;Becker S
通讯作者：
Becker S
影响因子：
5.4
作者：
FARAH, MJ
通讯作者：
FARAH, MJ
影响因子：
3.5
作者：
Barnabe, Alexandra;Whitehead, Victor;Chertkow, Howard
通讯作者：
Chertkow, Howard
影响因子：
4.1
作者：
FARAH, MJ
通讯作者：
FARAH, MJ
影响因子：
2.6
作者：
Irish, M.;Hornberger, M.;Piguet, O.
通讯作者：
Piguet, O.