On and off retinal circuit assembly by divergent molecular mechanisms.
On and off retinal circuit assembly by divergent molecular mechanisms.
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DOI：
10.1126/science.1241974
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发表时间：
2013-11-01
期刊：
影响因子：
--
通讯作者：
Kolodkin AL
中科院分区：
文献类型：
--
作者：
Sun LO;Jiang Z;Rivlin-Etzion M;Hand R;Brady CM;Matsuoka RL;Yau KW;Feller MB;Kolodkin AL
Direction-selective responses to motion can be to the onset (On) or cessation (Off) of illumination. Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and normal SAC stratification in the mouse retina. Plexin A2 is expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs. Specific On-Off bistratified direction-selective ganglion cells in semaphorin 6A−/− mutants exhibit decreased tuning of On directional motion responses. These results correlate the elaboration of symmetric SAC dendritic morphology and asymmetric responses to motion, shedding light on the development of visual pathways that use the same cell types for divergent outputs.
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DOI：
10.1523/jneurosci.0907-11.2011
发表时间：
2011-05-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kay JN;De la Huerta I;Kim IJ;Zhang Y;Yamagata M;Chu MW;Meister M;Sanes JR
通讯作者：
Sanes JR
影响因子：
64.8
作者：
Euler, T;Detwiler, PB;Denk, W
通讯作者：
Denk, W
DOI：
10.1523/jneurosci.0564-11.2011
发表时间：
2011-06-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Rivlin-Etzion M;Zhou K;Wei W;Elstrott J;Nguyen PL;Barres BA;Huberman AD;Feller MB
通讯作者：
Feller MB
影响因子：
15.9
作者：
Wei W;Feller MB
通讯作者：
Feller MB
影响因子：
2.5
作者：
Peters, BN;Masland, RH
通讯作者：
Masland, RH