Inflammatory mechanisms of idiopathic epiretinal membrane formation.

Inflammatory mechanisms of idiopathic epiretinal membrane formation.
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特发性前膜形成的炎症机制。

DOI:
10.1155/2013/192582
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发表时间:
2013
影响因子:
4.6
通讯作者:
Christoforidis JB
Christoforidis JB
中科院分区:
医学3区
文献类型:
--
作者:
Joshi M;Agrawal S;Christoforidis JB

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特发性视网膜前膜(iERMs)是视网膜临床常见的一种病理,其发病机制至今仍未得到研究人员的明确。过去对ierm的超微结构研究未能确定细胞的起源,因为细胞在转分化过程中发生了惊人的形态变化。因此,染色细胞结构成分的免疫组织化学技术证实了胶质细胞和透明细胞在iERM形成中的重要性。iERM的细胞成分被认为由胶质细胞、成纤维细胞、透明细胞等组成,它们与玻璃体中存在的细胞因子和生长因子协同作用,导致iERM的形成。最近,研究集中在后透明体在iERM形成和收缩中的作用,特别是异常PVD的过程,因为它与iERM的形成有关。蛋白质组学技术的最新进展也阐明了参与iERM形成的生长因子和细胞因子,其中最著名的是神经生长因子、胶质细胞系来源的生长因子和转化生长因子β1。
The pathogenesis of idiopathic epiretinal membranes (iERMs), a common pathology found in retina clinics, still eludes researchers to date. Ultrastructural studies of iERMs in the past have failed to identify the cells of origin due to the striking morphologic changes of cells involved via transdifferentiation. Thus, immunohistochemical techniques that stain for the cytostructural components of cells have confirmed the importance of glial cells and hyalocytes in iERM formation. The cellular constituents of iERMs are thought to consist of glial cells, fibroblasts, hyalocytes, etc. that, in concert with cytokines and growth factors present in the vitreous, lead to iERM formation. Recently, research has focused on the role of the posterior hyaloid in iERM formation and contraction, particularly the process of anomalous PVD as it relates to iERM formation. Recent advances in proteomics techniques have also elucidated the growth factors and cytokines involved in iERM formation, most notably nerve growth factor, glial cell line-derived growth factor, and transforming growth factor β1.
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