Neural mechanisms of social homeostasis.
Neural mechanisms of social homeostasis.
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DOI：
10.1111/nyas.14016
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发表时间：
2019-12
影响因子：
5.2
通讯作者：
Tye KM
中科院分区：
文献类型：
--
作者：
Matthews GA;Tye KM
社会关系对整个动物王国的生存至关重要，并且在整个生命周期中都是动态的。社会隔离和孤独会造成衰弱的后果，社会支持日益成为保健、疾病预防和康复方面的首要考虑因素。考虑到社会联系是一种“天生的需要”，假设进化上保守的神经系统是维持社会联系的基础：提醒个体他们的缺失，协调效应机制来恢复社会联系。这让人想起一个旨在维持社会联系的稳态系统。在这里，我们探索调节“社会稳态”的神经系统的身份。我们回顾了啮齿类动物对社会缺陷（以急性社会孤立的形式）的快速反应的研究结果，并提出平行的、重叠的回路是用来适应孤立的脆弱性和恢复社会联系的。通过考虑调节其他内稳态需求的神经系统，如能量和流体平衡，我们讨论了社会内稳态回路的潜在属性。我们认为，揭示这些回路/机制的身份将有助于我们理解孤独是如何使长期疾病状态永久化的，我们推测这可能是社会稳态回路持续招募的结果。在这里，我们探索调节“社会稳态”的神经系统的身份。我们回顾了啮齿类动物对社会缺陷（以急性社会孤立的形式）的快速反应的研究结果，并提出平行的、重叠的回路是用来适应孤立的脆弱性和恢复社会联系的。通过考虑调节其他内稳态需求的神经系统，如能量和流体平衡，我们讨论了社会内稳态回路的潜在属性。
Social connections are vital to survival throughout the animal kingdom and are dynamic across the lifespan. There are debilitating consequences of social isolation and loneliness, and social support is increasingly a primary consideration in healthcare, disease prevention, and recovery. Considering social connection as an “innate need,” it is hypothesized that evolutionarily conserved neural systems underlie the maintenance of social connections: alerting the individual to their absence and coordinating effector mechanisms to restore social contact. This is reminiscent of a homeostatic system designed to maintain social connection. Here, we explore the identity of neural systems regulating “social homeostasis.” We review findings from rodent studies evaluating the rapid response to social deficit (in the form of acute social isolation) and propose that parallel, overlapping circuits are engaged to adapt to the vulnerabilities of isolation and restore social connection. By considering the neural systems regulating other homeostatic needs, such as energy and fluid balance, we discuss the potential attributes of social homeostatic circuitry. We reason that uncovering the identity of these circuits/mechanisms will facilitate our understanding of how loneliness perpetuates long-term disease states, which we speculate may result from sustained recruitment of social homeostatic circuits. Here, we explore the identity of neural systems regulating “social homeostasis.” We review findings from rodent studies evaluating the rapid response to social deficit (in the form of acute social isolation) and propose that parallel, overlapping circuits are engaged to adapt to the vulnerabilities of isolation and restore social connection. By considering the neural systems regulating other homeostatic needs, such as energy and fluid balance, we discuss the potential attributes of social homeostatic circuitry.
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影响因子：
16.2
作者：
Burnett CJ;Li C;Webber E;Tsaousidou E;Xue SY;Brüning JC;Krashes MJ
通讯作者：
Krashes MJ
影响因子：
25
作者：
Burgos-Robles A;Kimchi EY;Izadmehr EM;Porzenheim MJ;Ramos-Guasp WA;Nieh EH;Felix-Ortiz AC;Namburi P;Leppla CA;Presbrey KN;Anandalingam KK;Pagan-Rivera PA;Anahtar M;Beyeler A;Tye KM
通讯作者：
Tye KM
DOI：
10.1098/rspb.2017.0515
发表时间：
2017-05-17
影响因子：
4.7
作者：
Brent, L. J. N.;Ruiz-Lambides, A.;Platt, M. L.
通讯作者：
Platt, M. L.
影响因子：
3.7
作者：
Bosch OJ;Dabrowska J;Modi ME;Johnson ZV;Keebaugh AC;Barrett CE;Ahern TH;Guo J;Grinevich V;Rainnie DG;Neumann ID;Young LJ
通讯作者：
Young LJ
影响因子：
64.5
作者：
Anderson DJ;Adolphs R
通讯作者：
Adolphs R