High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression.
High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression.
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DOI：
10.1016/j.jad.2018.02.024
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发表时间：
2018-05
影响因子：
6.6
通讯作者：
Yang TT
中科院分区：
文献类型：
--
作者：
Tymofiyeva O;Henje Blom E;Ho TC;Connolly CG;Lindqvist D;Wolkowitz OM;Lin J;LeWinn KZ;Sacchet MD;Han LKM;Yuan JP;Bhandari SP;Xu D;Yang TT
青少年焦虑和抑郁是一种高度流行的精神疾病，与分子和神经回路的改变有关。最近，线粒体DNA拷贝数（mtDNA-cn）增加已被发现与成人的几种精神病理学，特别是焦虑和抑郁症。然而，尚未在青少年中调查mtDNA-cn与焦虑和抑郁之间的关联。此外，到目前为止，还没有研究检查mtDNA-cn与任何年龄组心境障碍的脑网络改变之间的关联。本研究的第一个目的是比较49名抑郁和/或焦虑的青少年和35名匹配良好的健康对照之间的唾液mtDNA-cn。本研究的第二个目的是确定神经相关的mtDNA-cn来自扩散张量成像（DTI）和纤维束成像，在整个样本的青少年。mtDNA-cn无诊断特异性改变。然而，在整个青少年样本中，mtDNA-cn与焦虑水平呈正相关，而与抑郁水平无关。在mtDNA-cn高于中位数的青少年中，主要对应于左侧额枕束的连接子网络具有显著较低的各向异性分数（FA）值。游离和细胞内mtDNA的未分化分析和基于DTI的纤维束成像的使用代表了本研究的局限性。这项研究的结果有助于阐明临床症状之间的关系，分子变化，和神经回路改变青少年和没有焦虑和抑郁症，他们认为，增加mtDNA-cn与焦虑症状增加和减少额枕结构连接在这个人群。
Adolescent anxiety and depression are highly prevalent psychiatric disorders that are associated with altered molecular and neurocircuit profiles. Recently, increased mitochondrial DNA copy number (mtDNA-cn) has been found to be associated with several psychopathologies in adults, especially anxiety and depression. The associations between mtDNA-cn and anxiety and depression have not, however, been investigated in adolescents. Moreover, to date there have been no studies examining associations between mtDNA-cn and brain network alterations in mood disorders in any age group. The first aim of this study was to compare salivary mtDNA-cn between 49 depressed and/or anxious adolescents and 35 well-matched healthy controls. The second aim of this study was to identify neural correlates of mtDNA-cn derived from diffusion tensor imaging (DTI) and tractography, in the full sample of adolescents. There were no diagnosis-specific alterations in mtDNA-cn. However, there was a positive correlation between mtDNA-cn and levels of anxiety, but not depression, in the full sample of adolescents. A subnetwork of connections largely corresponding to the left fronto-occipital fasciculus had significantly lower fractional anisotropy (FA) values in adolescents with higher than median mtDNA-cn. Undifferentiated analysis of free and intracellular mtDNA and use of DTI-based tractography represent this study’s limitations. The results of this study help elucidate the relationships between clinical symptoms, molecular changes, and neurocircuitry alterations in adolescents with and without anxiety and depression, and they suggest that increased mtDNA-cn is associated both with increased anxiety symptoms and with decreased fronto-occipital structural connectivity in this population.
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影响因子：
6.1
作者：
Garibotto, V.;Scifo, P.;Perani, D.
通讯作者：
Perani, D.
DOI：
10.1016/j.jaac.2014.04.021
发表时间：
2014-08
影响因子：
13.3
作者：
LeWinn, Kaja Z.;Connolly, Colm G.;Wu, Jing;Drahos, Miroslav;Hoeft, Fumiko;Ho, Tiffany C.;Simmons, Alan N.;Yang, Tony T.
通讯作者：
Yang, Tony T.
影响因子：
7.6
作者：
Huang, Hao;Gundapuneedi, Tejasvi;Rao, Uma
通讯作者：
Rao, Uma
影响因子：
3.7
作者：
Aschbacher, Kirstin;O'Donovan, Aoife;Wolkowitz, Owen M.;Dhabhar, Firdaus S.;Su, Yali;Epel, Elissa
通讯作者：
Epel, Elissa
影响因子：
5.7
作者：
Griffa, Alessandra;Baumann, Philipp S.;Hagmann, Patric
通讯作者：
Hagmann, Patric