White matter correlates of adolescent depression: structural evidence for frontolimbic disconnectivity.
White matter correlates of adolescent depression: structural evidence for frontolimbic disconnectivity.
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DOI：
10.1016/j.jaac.2014.04.021
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发表时间：
2014-08
影响因子：
13.3
通讯作者：
Yang, Tony T.
中科院分区：
文献类型：
--
作者：
LeWinn, Kaja Z.;Connolly, Colm G.;Wu, Jing;Drahos, Miroslav;Hoeft, Fumiko;Ho, Tiffany C.;Simmons, Alan N.;Yang, Tony T.
关键词：
尽管青少年抑郁症发病率很高，但人们对这种疾病的神经解剖学基础知之甚少。额边缘回路的功能失调被认为是成年和青少年抑郁症阻碍情绪调节的关键神经相关因素。然而，很少有人知道这种失调是否覆盖在受损的白色物质的微观结构。在神经影像学研究结果的指导下，我们检验了青少年抑郁症与1）钩束（UF）和2）扣带束中白色物质微结构改变相关的先验假设。对52例未服药的青少年抑郁症（MDD）和42例对照组进行弥散张量磁共振成像（DTI）。我们计算了双侧UF和扣带回的各向异性分数（FA）、径向扩散率（RD）和轴向扩散率（AD）。我们还使用基于轨迹的空间统计（TBSS）对抑郁症患者和对照组患者进行了体素比较。青少年抑郁症患者双侧UF的FA显著降低，RD显著升高;扣带回无显著差异。TBSS结果还显示，与边缘-皮质-纹状体-丘脑回路、胼胝体、前放射冠和上级放射冠相关的白色物质的FA值较低。未用药的青少年抑郁症与情绪调节网络的各向异性分数降低有关，这可能是抑郁症特征性额边缘回路功能差异的基础。鉴于我们的样本中抑郁症的发病时间相对较晚，我们在当前文献背景下的研究结果提供了初步证据，即UF中各向异性分数的降低可能是抑郁症的易感风险因素。
Despite the significant prevalence of adolescent depression, little is known about the neuroanatomical basis of this disorder. Functional dysregulation in frontolimbic circuitry has been suggested as a key neural correlate of adult and adolescent depression impeding emotional regulation. However, less is known about whether this dysregulation is overlaid on impaired white matter microstructure. Guided by neuroimaging findings, we test the a priori hypotheses that adolescent depression is associated with alterations in white matter microstructure in the 1) uncinate fasciculus (UF) and 2) cingulum bundles. Diffusion tensor magnetic resonance imaging (DTI) data were obtained on 52 unmedicated adolescents with major depressive disorder (MDD) and 42 matched controls. We calculated fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD) for bilateral UF and cingulum. We also completed a voxelwise comparison of participants with depression and control participants using tract-based spatial statistics (TBSS). Adolescents with depression had significantly lower FA and higher RD in bilateral UF; no significant differences were observed in cingulum. TBSS results additionally revealed lower FA values in the white matter associated with the limbic-cortical-striatal-thalamic circuit, corpus callosum, and anterior and superior corona radiata. Unmedicated adolescent depression is associated with reduced fractional anisotropy in emotion regulatory networks, which may underlie the functional differences in frontolimbic circuitry characterizing depressive disorder. Given the relatively recent onset of depression in our sample, our findings in the context of the current literature provide preliminary evidence that reduced fractional anisotropy in the UF could be a predisposing risk factor for depression.
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DOI：
10.1016/j.jaac.2013.07.008
发表时间：
2013-10
影响因子：
13.3
作者：
Ho TC;Wu J;Shin DD;Liu TT;Tapert SF;Yang G;Connolly CG;Frank GK;Max JE;Wolkowitz O;Eisendrath S;Hoeft F;Banerjee D;Hood K;Hendren RL;Paulus MP;Simmons AN;Yang TT
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DOI：
10.1016/j.jaac.2009.11.005
发表时间：
2010-02-01
影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
10.6
作者：
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通讯作者：
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影响因子：
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Sherr EH