Rational design of nanofiber scaffolds for orthopedic tissue repair and regeneration.
Rational design of nanofiber scaffolds for orthopedic tissue repair and regeneration.
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DOI：
10.2217/nnm.13.132
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Bartlett DE
中科院分区：
文献类型：
--
作者：
Ma B;Xie J;Jiang J;Shuler FD;Bartlett DE
本文综述了近年来纳米纤维支架在骨科组织修复和再生方面的重大进展。它首先简要介绍了目前骨科组织修复和再生方法的局限性。然后，它说明了合理设计的由静电纺纳米纤维组成的支架可能是克服当前方法遇到的问题的有希望的解决方案。本文还讨论了电纺纳米纤维的有趣特性，包括组成、结构、顺序、排列和机械性能的控制，用作局部药物和/或基因持续递送的载体，以及作为调节细胞行为的底物，这可能有利于肌肉骨骼组织的修复和再生。进一步介绍了近年来静电纺纳米纤维支架在各种骨科组织修复和再生中的应用。最后，对纳米纤维支架在骨科组织工程中的设计、制造和应用面临的挑战和未来发展方向进行了展望。
This article reviews recent significant advances in the design of nanofiber scaffolds for orthopedic tissue repair and regeneration. It begins with a brief introduction on the limitations of current approaches for orthopedic tissue repair and regeneration. It then illustrates that rationally designed scaffolds made up of electrospun nanofibers could be a promising solution to overcome the problems that current approaches encounter. The article also discusses the intriguing properties of electrospun nanofibers, including control of composition, structures, orders, alignments and mechanical properties, use as carriers for topical drug and/or gene sustained delivery, and serving as substrates for the regulation of cell behaviors, which could benefit musculoskeletal tissue repair and regeneration. It further highlights a few of the many recent applications of electrospun nanofiber scaffolds in repairing and regenerating various orthopedic tissues. Finally, the article concludes with perspectives on the challenges and future directions for better design, fabrication and utilization of nanofiber scaffolds for orthopedic tissue engineering.
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