Case Report: Sars-CoV-2 Infection in a Vaccinated Individual: Evaluation of the Immunological Profile and Virus Transmission Risk.
Case Report: Sars-CoV-2 Infection in a Vaccinated Individual: Evaluation of the Immunological Profile and Virus Transmission Risk.
复制标题
DOI：
10.3389/fimmu.2021.708820
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Giardina E
中科院分区：
文献类型：
--
作者：
Strafella C;Caputo V;Guerrera G;Termine A;Fabrizio C;Cascella R;Picozza M;Caltagirone C;Rossini A;Balice MP;Salvia A;Battistini L;Borsellino G;Giardina E
在COVID 19大流行期间，一系列疫苗在预防疾病、严重感染后果和死亡率方面表现出很高的效力。然而，保护的免疫学相关性、免疫应答的持续时间、接种个体随时间的传播风险目前正在积极调查中。在这份简短的报告中，我们描述了一名接种疫苗的医疗保健专业人员感染SARS-CoV-2变体的病例，为了绘制完整的感染轨迹，对该病例进行了广泛的调查。监测患者感染的整个持续时间，评估暂时病毒载量衰减、病毒RNA和亚基因组mRNA的定量、抗体（抗Sars-CoV-2、伊加、IgG、IgM）和细胞介导的（细胞因子、B细胞和T细胞谱）应答。总体而言，这份简短的报告强调了疫苗在预防COVID-19疾病，加速感染恢复，降低传播风险方面的有效性，尽管使用预防措施防止SARS-CoV-2传播仍然至关重要。
During the COVID19 pandemic, a range of vaccines displayed high efficacy in preventing disease, severe outcomes of infection, and mortality. However, the immunological correlates of protection, the duration of immune response, the transmission risk over time from vaccinated individuals are currently under active investigation. In this brief report, we describe the case of a vaccinated Healthcare Professional infected with a variant of Sars-CoV-2, who has been extensively investigated in order to draw a complete trajectory of infection. The patient has been monitored for the whole length of infection, assessing the temporal viral load decay, the quantification of viral RNA and subgenomic mRNA, antibodies (anti Sars-CoV-2, IgA, IgG, IgM) and cell-mediated (cytokine, B- and T-cell profiles) responses. Overall, this brief report highlights the efficacy of vaccine in preventing COVID19 disease, accelerating the recovery from infection, reducing the transmission risk, although the use of precautionary measures against Sars-CoV-2 spreading still remain critical.
登录
查看更多内容
影响因子：
82.9
作者：
Levine-Tiefenbrun, Matan;Yelin, Idan;Kishony, Roy
通讯作者：
Kishony, Roy
影响因子：
64.5
作者：
Moderbacher, Carolyn Rydyznski;Ramirez, Sydney, I;Crotty, Shane
通讯作者：
Crotty, Shane
影响因子：
64.5
作者：
Sekine, Takuya;Perez-Potti, Andre;Buggert, Marcus
通讯作者：
Buggert, Marcus
影响因子：
24.8
作者：
Weiskopf, Daniela;Schmitz, Katharina S.;de Vries, Rory D.
通讯作者：
de Vries, Rory D.
影响因子：
8.8
作者：
Tan AT;Linster M;Tan CW;Le Bert N;Chia WN;Kunasegaran K;Zhuang Y;Tham CYL;Chia A;Smith GJD;Young B;Kalimuddin S;Low JGH;Lye D;Wang LF;Bertoletti A
通讯作者：
Bertoletti A