Numerical modeling of the flow in intracranial aneurysms: prediction of regions prone to thrombus formation.
Numerical modeling of the flow in intracranial aneurysms: prediction of regions prone to thrombus formation.
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DOI：
10.1007/s10439-008-9561-5
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发表时间：
2008-11
影响因子：
3.8
通讯作者：
Saloner, D.
中科院分区：
文献类型：
--
作者：
Rayz, V. L.;Boussel, L.;Lawton, M. T.;Acevedo-Bolton, G.;Ge, L.;Young, W. L.;Higashida, R. T.;Saloner, D.
关键词：
颅内动脉瘤腔内血栓的沉积增加了血栓栓塞的风险，超过了质量效应和破裂造成的风险。除了生化因素之外，由管腔几何形状和血液流速控制的血液动力学因素可能在血栓形成和沉积过程中起重要作用。在本研究中，根据3例梭形基底动脉瘤患者的MRA数据构建了患者特定的血流计算流体动力学（CFD）模型，这些患者无血栓，然后继续发展腔内血栓。为了确定流场的特征是否可以表明哪些区域具有较高的血栓沉积可能性，在基线、无血栓几何形状中对流动进行建模。脉动流模拟进行了使用患者特定的入口流量条件下测量的MR测速仪。考虑了牛顿和非牛顿血液行为。CFD预测的缓慢再循环流动的动脉瘤内区域与后续MR研究中体内观察到的血栓沉积区域之间存在很强的相似性。在两个较大动脉瘤的病例中，当考虑到非牛顿血液行为时，低速区和凝块区之间的一致性得到改善。在计算的低剪切应力区域和后来观察到凝块的区域之间也发现了相似性。
The deposition of intralumenal thrombus in intracranial aneurysms adds a risk of thrombo-embolism over and above that posed by mass-effect and rupture. In addition to biochemical factors, hemodynamic factors that are governed by lumenal geometry and blood flow rates likely play an important role in the thrombus formation and deposition process. In this study, patient-specific computational fluid dynamics (CFD) models of blood flow were constructed from MRA data for three patients who had fusiform basilar aneurysms that were thrombus-free and then proceeded to develop intra-lumenal thrombus. In order to determine whether features of the flow fields could suggest which regions had an elevated potential for thrombus deposition, the flow was modeled in the baseline, thrombus-free geometries. Pulsatile flow simulations were carried out using patient-specific inlet flow conditions measured with MR velocimetry. Newtonian and non-Newtonian blood behavior was considered. A strong similarity was found between the intra-aneurysmal regions with CFD-predicted slow, recirculating flows and the regions of thrombus deposition observed in vivo in the follow-up MR studies. In two cases with larger aneurysms, the agreement between the low velocity zones and clotted off regions improved when non-Newtonian blood behavior was taken into account. A similarity was also found between the calculated low shear stress regions and the regions that were later observed to clot.
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影响因子：
2.4
作者：
Johnston, BM;Johnston, PR;Kilpatrick, D
通讯作者：
Kilpatrick, D
DOI：
10.1115/1.2898833
发表时间：
2008-04-01
影响因子：
1.7
作者：
Rayz, Vitaliy L.;Lawton, Michael T.;Saloner, David
通讯作者：
Saloner, David
影响因子：
2.4
作者：
Tu, C;Deville, M
通讯作者：
Deville, M
影响因子：
10.6
作者：
Cebral, JR;Castro, MA;Frangi, AF
通讯作者：
Frangi, AF
影响因子：
3.8
作者：
Humphrey, JD;Na, S
通讯作者：
Na, S