Paternal treadmill exercise enhances spatial learning and memory related to hippocampus among male offspring
Paternal treadmill exercise enhances spatial learning and memory related to hippocampus among male offspring
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父亲跑步机运动增强男性后代与海马体相关的空间学习和记忆
DOI：
10.1016/j.bbr.2013.07.040
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发表时间：
2013-09
影响因子：
2.7
通讯作者：
傅力
中科院分区：
文献类型：
--
作者：
尹苗苗;王巍;孙婧;刘素;刘效磊;牛燕媚;袁海瑞;杨风英;傅力
流行病学和实验室研究都表明，父母可以塑造子女的发育。最近，有研究表明，孕期母体锻炼有益于后代的大脑功能。然而，关于父性锻炼对后代表型的影响，人们知之甚少。在这项研究中，我们试图确定6周的父亲跑步机运动对其雄性后代空间学习和记忆以及脑源性神经营养因子(BDNF)和reelin表达的影响。兄弟姐妹男性被分成两组：对照组(C)和运动组(E)。E组小鼠在电动跑步机上运动，每周5天，连续6周。经过6周的锻炼，雄性小鼠与其兄弟姐妹雌性小鼠交配。断奶后，雄性幼鼠接受行为评估(Open field和Morris水迷宫测试)。用免疫组织化学染色、实时定量聚合酶链式反应和免疫印迹法检测行为任务结束后雄性幼鼠海马区BDNF和reelin的表达。结果表明，与C组相比，父亲跑台运动改善了雄性幼鼠的空间学习记忆能力，并伴随着BDNF和reelin表达的显著增加。我们的结果提供了新的证据，证明父亲的跑步机锻炼可以增强他们F1雄性后代的大脑功能。
Both epidemiologic and laboratory studies suggest that parents can shape their offspring's development. Recently, it has been shown that maternal exercise during pregnancy benefits the progeny's brain function. However, little is known regarding the influence of paternal exercise on their offspring's phenotype. In this study we attempt to determine the effects of 6 weeks paternal treadmill exercise on spatial learning and memory and the expression of brain-derived neurotrophic factor (BDNF) and reelin in their male offspring. Sibling males were divided into two groups: the control (C) and the exercise group (E). The mice in the E group were exercised on a motor-driven rodent treadmill for 5 days per week for 6 weeks. After 6 weeks of exercise, the male mouse was mated with its sibling female. After weaning, male pups underwent behavioral assessment (Open field and Morris water maze tests). Immunohistochemistry staining, real time-PCR and western blot were performed to determine hippocampal BDNF and reelin expression of the male pups after behavior tasks. Our results showed that paternal treadmill exercise improved the spatial learning and memory capability of male pups, which was accompanied by significantly increased expression of BDNF and reelin, as compared to those of C group. Our results provide novel evidence that paternal treadmill exercise can enhance the brain functions of their F1 male offspring.
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怀孕期间运动对新生儿大脑的影响：随机对照试验的研究方案。
影响因子：
2.5
作者：
LeMoyne EL;Curnier D;St-Jacques S;Ellemberg D
通讯作者：
Ellemberg D
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3.4
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Berchtold, NC;Kesslak, JP;Cotman, CW
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Cotman, CW
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van Praag, H;Shubert, T;Gage, FH
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Gage, FH
影响因子：
25
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van Praag, H;Kempermann, G;Gage, FH
通讯作者：
Gage, FH
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--
作者：
Laurin, D;Verreault, R;Rockwood, K
通讯作者：
Rockwood, K