Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometry.
Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometry.
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DOI：
10.1186/1617-9625-10-7
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发表时间：
2012-05-21
影响因子：
3.7
通讯作者：
Méndez JA
中科院分区：
文献类型：
--
作者：
Fernández JA;Prats JM;Artero JV;Mora AC;Fariñas AV;Espinal A;Méndez JA
吸烟与低度全身性炎症有关，这是一种已知的疾病风险因素。这种状态反映在白色血细胞（WBC）计数升高。我们分析了白细胞计数和吸烟之间的关系，在几个年龄段的健康男性和女性谁在工作场所进行预防性体检。我们还分析了吸烟与肺功能的关系。横断面描述性研究，163 459名男性和59 382名女性，年龄在16至70岁之间。分析的数据包括吸烟状况、WBC计数和肺量测定读数。男性和女性吸烟者的白细胞总数均高于男性，约为1000 ~ 1300个/ml（t检验，P < 0.001）。在25 ~ 54岁年龄组中，不吸烟者的第一秒用力呼气量（FEV1%）高于不吸烟者（t检验，P < 0.001）。协方差分析显示年龄、性别、吸烟状况、体重指数对白细胞计数有多因素影响。WBC血细胞计数和吸烟状态之间的关系得到证实后，样本分层这些变量。在年龄和BMI相似的组中，与FEV1%正常的吸烟者相比，通过FEV1%测量的气道阻塞的吸烟者具有更高的WBC计数。吸烟会增加白细胞计数，影响肺功能。这种影响在很大的年龄范围内都很明显，强调了一旦个人开始吸烟就采取预防措施的重要性。
Smoking has been linked to low-grade systemic inflammation, a known risk factor for disease. This state is reflected in elevated white blood cell (WBC) count. We analyzed the relationship between WBC count and smoking in healthy men and women across several age ranges who underwent preventive medical check-ups in the workplace. We also analysed the relationship between smoking and lung function. Cross-sectional descriptive study in 163 459 men and 59 382 women aged between 16 and 70 years. Data analysed were smoking status, WBC count, and spirometry readings. Total WBC showed higher counts in both male and female smokers, around 1000 to 1300 cell/ml (t test, P < 0.001). Forced expiratory volume in 1 second (FEV1%) was higher in nonsmokers for both sexes between 25 to 54 years (t test, P < 0.001). Analysis of covariance showed a multiple variable effect of age, sex, smoking status, body mass index on WBC count. The relationship between WBC blood count and smoking status was confirmed after the sample was stratified for these variables. Smokers with airway obstruction measured by FEV1% were found to have higher WBC counts, in comparison to smokers with a normal FEV1% among similar age and BMI groups. Smoking increases WBC count and affects lung function. The effects are evident across a wide age range, underlining the importance of initiating preventive measures as soon as an individual begins to smoke.
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影响因子：
3.4
作者：
Roethig, Hans J.;Koval, Tamara;Unverdorben, Martin
通讯作者：
Unverdorben, Martin
影响因子：
5
作者：
NIETO, FJ;SZKLO, M;MERCURI, M
通讯作者：
MERCURI, M
影响因子：
37.8
作者：
TELL, GS;GRIMM, RH;THEODORSEN, L
通讯作者：
THEODORSEN, L
影响因子：
1.9
作者：
Huang, ZS;Chien, KL;Wang, CH
通讯作者：
Wang, CH
影响因子：
3.4
作者：
YARNELL, JWG;SWEETNAM, PM;ETHERINGTON, MD
通讯作者：
ETHERINGTON, MD