Photo-cross-linked PDMSstar-PEG hydrogels: synthesis, characterization, and potential application for tissue engineering scaffolds.
Photo-cross-linked PDMSstar-PEG hydrogels: synthesis, characterization, and potential application for tissue engineering scaffolds.
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DOI：
10.1021/bm9012293
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发表时间：
2010-03-08
影响因子：
6.2
通讯作者：
Grunlan, Melissa A.
中科院分区：
文献类型：
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作者：
Hou, Yaping;Schoener, Cody A.;Regan, Katherine R.;Munoz-Pinto, Dany;Hahn, Mariah S.;Grunlan, Melissa A.
以甲基丙烯酸酯化的星星型聚二甲基硅氧烷（PDMSstar-MA）和二丙烯酸酯化的聚乙二醇（PEG-DA）为原料，制备了理化性质可调的无机-有机水凝胶，用于组织工程支架。通过光交联不同重量比的不同分子量（Mn）的PEG-DA和PDMSstar-MA：PEG-DA（Mn = 3.4k和6 k g/mol）和PDMSstar-MA（Mn = 1.8k、5 k和7 k g/mol）制备了十八种组成独特的水凝胶。PDMSstar-MA的引入引起分散在PEG基质内的离散的富含PDMS的微粒的形成。研究了水凝胶的溶胀率、拉伸和压缩力学性能、非特异性蛋白质粘附、生物活性的可控引入和细胞毒性。这个具有可调特性的无机-有机水凝胶库为研究支架特性对细胞行为的影响提供了一个有用的平台。
Inorganic-organic hydrogels with tunable chemical and physical properties were prepared from methacrylated star polydimethylsiloxane (PDMSstar-MA) and diacrylated poly(ethylene glycol) (PEG-DA) for use as tissue engineering scaffolds. Eighteen compositionally unique hydrogels were prepared by photo-crosslinking varying weight ratios of PEG-DA and PDMSstar-MA of different molecular weights (Mn): PEG-DA (Mn = 3.4k and 6k g/mol) and PDMSstar-MA (Mn = 1.8k, 5k and 7k g/mol). Introduction of PDMSstar-MA caused formation of discrete PDMS-enriched microparticles dispersed within the PEG matrix. The swelling ratio, mechanical properties in tension and compression, non-specific protein adhesion, controlled introduction of bioactivity and cytotoxicity of hydrogels were studied. This library of inorganic-organic hydrogels with tunable properties provides a useful platform to study the effect of scaffold properties on cell behavior.
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影响因子：
14
作者：
Causa, Filippo;Netti, Paolo A.;Ambrosio, Luigi
通讯作者：
Ambrosio, Luigi
影响因子：
3.6
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影响因子：
14
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影响因子：
3.6
作者：
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通讯作者：
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影响因子：
41.2
作者：
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