Prognostic effects of the gastric mucosal microbiota in gastric cancer.
Prognostic effects of the gastric mucosal microbiota in gastric cancer.
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胃癌是最常见的恶性肿瘤之一，发病率和死亡率都很高。微生物群在人类健康和疾病中发挥着重要作用。我们的目的是研究不同胃微生境中胃微生物群的预后价值。我们使用了我们以前发表的16S rRNA基因序列数据。我们回顾性地招募了132名具有完整预后信息的GC患者，并选择了78个正常组织，49个肿瘤周围组织和112个肿瘤组织进行微生物群分析。不同胃肠道疾病的患者表现出不同的胃微生物群组成和多样性。在消化不良患者中，丰富的胃微生物群的关联网络更加复杂。在肿瘤周围的微生境的良好的牙周炎患者，螺杆菌显着增加，而盐单胞菌和希瓦氏菌显着减少，相对于在肿瘤周围的微生境的穷人牙周炎患者。PiCRUSt分析显示，与肿瘤和正常微生物群相比，肿瘤周围微生物群具有更多不同的京都基因百科全书和基因组途径。这项研究评估了胃癌患者胃粘膜微生物群的长期预后价值。这些发现表明，胃粘膜微生物群的特征性改变可能是这些患者临床结局的标志物。微生物群在人类健康和疾病中发挥着重要作用。不同胃癌患者的胃内微生物群组成和多样性不同。胃粘膜微生物群的特征性变化可能是这些患者临床结果的标志物。
Gastric cancer (GC) is one of the most common malignant tumors with a high incidence and mortality. Microbiota play a significant role in human health and disease. We aimed to investigate the prognostic value of the gastric microbiota in different stomach microhabitats. We used our previously published 16S rRNA gene sequence data. We retrospectively enrolled a cohort of 132 patients with GC with complete prognostic information and selected 78 normal tissues, 49 peritumoral tissues, and 112 tumoral tissues for microbiota analysis. Patients with different prognoses showed different gastric microbiota compositions and diversity. The association network of the abundant gastric microbiota was more complicated in patients with poor prognoses. In the peritumoral microhabitat of patients with good prognoses, Helicobacter was significantly increased, whereas Halomonas and Shewanella were significantly decreased relative to that in the peritumoral microhabitat of patients with poor prognoses. PiCRUSt analysis revealed that the peritumoral microbiota had more different Kyoto Encyclopedia of Genes and Genomes pathways than did the tumoral and normal microbiota. This study evaluated the long‐term prognostic value of the gastric mucosal microbiota in patients with GC. These findings suggested that the characteristic alterations of the gastric mucosal microbiota may be markers for clinical outcomes in these patients. Microbiota play a significant role in human health and disease. Gastric cancer (GC) patients with different prognoses showed different gastric microbiota compositions and diversity. The characteristic alterations of the gastric mucosal microbiota may be markers for clinical outcomes in these patients.
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