Adolescent cortisol and DHEA responses to stress as prospective predictors of emotional and behavioral difficulties: A person-centered approach.
Adolescent cortisol and DHEA responses to stress as prospective predictors of emotional and behavioral difficulties: A person-centered approach.
复制标题
DOI：
10.1016/j.psyneuen.2021.105365
复制
发表时间：
2021-10
影响因子：
3.7
通讯作者：
Klimes-Dougan B
中科院分区：
文献类型：
--
作者：
Bendezú JJ;Howland M;Thai M;Marceau K;Shirtcliff EA;Hastings PD;Zahn-Waxler C;Klimes-Dougan B
良好协调的皮质醇和脱氢表雄酮应激反应被认为支持有效的压力源管理(即应对)，并降低青春期精神病理的风险。然而，这些关系的证据缺乏经验证据。这项纵向调查有三个目的：1)确定青春期内皮质醇-脱氢表雄酮联合反应的概况，2)检验作为青少年未来情绪和行为困难的预期预测因子的概况，以及3)检验分心应对是否有助于缓冲每个概况中的此类预期风险。在第一时间，11至16岁的男孩(n=110)和女孩(n=105)完成了基于实验室的社会评估应激源和问卷(例如，应对、内在化和外在化问题)，这些人患精神病的风险程度不同。在时间2(2年后)再次评估情绪和行为适应。根据应激源对青少年皮质醇和脱氢表雄酮的多轨迹建模，发现三组：正常组(n=107；49.8%)，高反应组(n=，29.8%)，低反应组(n=44，20.5%)。与正常青少年相比，高反应青少年和低反应青少年在青春期阶段分别进步更多和更慢。与正常青少年相比，高反应青少年，但不是反应迟钝的青少年，在时间2报告了更多的情绪和行为问题。分心应对和第二时间适应之间的联系在不同的组中有所不同。具体地说，在正常青少年中，分心应对与较少的情感和行为问题有关。然而，对于反应迟钝的青少年来说，情况正好相反，分心与更长的时间情感和行为问题有关。分心与高反应性青少年的第二时间情绪和行为问题无关(即，无论分心应对利用率如何，分心水平都升高)。我们的结果加强了神经内分泌协调在精神病理风险中的作用的推断。研究结果还有助于澄清不一致的分心应对-精神病理学联系，说明皮质醇-脱氢表雄酮反应的不同模式，支持和阻碍这一潜在有效策略的使用。
Well-orchestrated cortisol and DHEA stress responsivity is thought to support efficacious stressor management (i.e., coping) and reduce risk for psychopathology during adolescence. Evidence of these relations, however, is lacking empirically. This longitudinal investigation had three aims: 1) to identify within-adolescent profiles of joint cortisol-DHEA responsivity, 2) examine profiles as prospective predictors of adolescents’ later emotional and behavioral difficulties, and 3) examine whether distraction coping helped buffer such prospective risk in each profile. At Time 1, boys (n=110) and girls (n=105) between 11 and 16 years of age with varied levels of risk for psychopathology completed a lab-based socio-evaluative stressor and questionnaires (e.g., coping, internalizing and externalizing problems). Emotional and behavioral adjustment was assessed again at Time 2 (2 years later). Multi-trajectory modeling of adolescents’ cortisol and DHEA within the context of the stressor revealed three groups: Normative (n=107; 49.8%), Hyperresponsive (n=64; 29.8%), Hyporesponsive (n=44; 20.5%). Relative to Normative, Hyperresponsive and Hyporesponsive adolescents were more and less advanced in pubertal status, respectively. Hyperresponsive adolescents, but not Hyporesponsive, reported greater emotional and behavioral problems at Time 2, relative to Normative adolescents. Links between distraction coping and Time 2 adjustment varied across the groups. Specifically, distraction coping was associated with fewer Time 2 emotional and behavioral problems for Normative adolescents. However, the converse was true for Hyporesponsive adolescents, with distraction associated with greater Time 2 emotional and behavioral problems. Distraction was not associated with Time 2 emotional and behavioral problems for Hyperresponsive adolescents (i.e., elevated levels irrespective of distraction coping utilization). Our results strengthen inference about the role neuroendocrine coordination plays in risk for psychopathology. Findings also help to clarify inconsistent distraction coping–psychopathology linkages, illustrating different patterns of cortisol-DHEA responsivity that support as well as thwart the use of this potentially efficacious strategy.
登录
查看更多内容
影响因子：
3.6
作者：
Hilt, Lori M.;McLaughlin, Katie A.;Nolen-Hoeksema, Susan
通讯作者：
Nolen-Hoeksema, Susan
影响因子：
2.6
作者：
Marceau, Kristine;Laurent, Heidemarie K.;Leve, Leslie D.
通讯作者：
Leve, Leslie D.
影响因子：
3.7
作者：
Pruessner, JC;Kirschbaum, C;Hellhammer, DH
通讯作者：
Hellhammer, DH
影响因子：
10.5
作者：
Goodyer, IM;Park, RJ;Herbert, J
通讯作者：
Herbert, J
影响因子：
4.6
作者：
NOLENHOEKSEMA, S
通讯作者：
NOLENHOEKSEMA, S