Mechanisms of Mitochondrial Redox Signaling in Psychosocial Stress-Responsive Systems: New Insights into an Old Story.
Mechanisms of Mitochondrial Redox Signaling in Psychosocial Stress-Responsive Systems: New Insights into an Old Story.
复制标题
心理社会压力反应系统中线粒体氧化还原信号传导的机制：对旧故事的新见解
DOI：
10.1089/ars.2017.7186
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发表时间：
2018
影响因子：
6.6
通讯作者：
中科院分区：
文献类型：
--
作者：
意义：心理社会应激与血清糖皮质激素和细胞因子（如白细胞介素-6（IL-6）和IL-1β）的变化相关，它们在功能上相互作用。然而，这两个系统之间的分子机制和生理关系的背景下，应激exposure.Recent Advances：细胞外IL-6，刺激皮质醇的释放从肾上腺皮质束状体，通过酪氨酸磷酸化的转录因子信号转导和转录激活因子3（STAT 3）介导其细胞内的影响。线粒体电子转移反应参与了STAT 3驱动的ATP生产在氧化呼吸和肾上腺皮质类固醇biosynthesis.Critical Issues：STAT 3在氧化呼吸和类固醇生成的作用表明，它整合了核和线粒体的行动，从而保留在肾上腺糖皮质激素生物合成的主要步骤下的心理压力。本文综述了这两种途径同时参与保护慢性stressors.Future Directions的概念：将细胞因子和下丘脑-垂体-肾上腺（HPA）轴的主要成分的功能与线粒体氧化还原信号传导的分子机制联系起来，对于更好地理解参与应激反应的相关应激反应系统至关重要。氧化还原信号。28，760-772。
Significance:Psychosocial stress is associated with alterations in serum glucocorticoids and cytokines, such as interleukin-6 (IL-6) and IL-1β, which functionally interact. However, the molecular mechanisms and physiological relationship between the two systems within the context of stress exposure are not well characterized.Recent Advances:Extracellular IL-6, which stimulates the release of cortisol from the zona fasciculata of the adrenal cortex, mediates its intracellular effects by tyrosine phosphorylation of the transcription factor signal transducer and activator of transcription 3 (STAT3). Mitochondrial electron transfer reactions are involved in both STAT3-driven ATP production in oxidative respiration and adrenocortical steroid biosynthesis.Critical Issues:The role of STAT3 in oxidative respiration and steroidogenesis suggests that it integrates both nuclear and mitochondrial actions, thereby preserving main steps of glucocorticoid biosynthesis in the adrenal gland under psychosocial stress. This review discusses the notion that these two pathways are together simultaneously involved in protection against chronic stressors.Future Directions:Linking the function of cytokines and main components of the hypothalamic–pituitary–adrenal (HPA) axis to molecular mechanisms of mitochondrial redox signaling will be essential for a better understanding of the relevant stress-responsive systems engaged in stress vulnerability.Antioxid. Redox Signal. 28, 760–772.
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DOI：
10.1210/jcem.81.7.8675562
发表时间：
1996-07
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
E. Cauter;R. Leproult;D. Kupfer
通讯作者：
E. Cauter;R. Leproult;D. Kupfer
影响因子：
56.9
作者：
MOUNTJOY, KG;ROBBINS, LS;CONE, RD
通讯作者：
CONE, RD
影响因子：
4.7
作者：
Nicolson, NA;van Diest, R
通讯作者：
van Diest, R
体外垂体前叶组织释放促肾上腺皮质激素。
DOI：
10.1139/o55-054
发表时间：
1955
期刊：
Canadian journal of biochemistry and physiology
影响因子：
--
作者：
M. Saffran;A. Schally
通讯作者：
A. Schally
影响因子：
15.1
作者：
Janszky, I;Lekander, M;Ahnve, S
通讯作者：
Ahnve, S