Differential effects of endocrine dysfunction on the axial and the appendicular skeleton.
Differential effects of endocrine dysfunction on the axial and the appendicular skeleton.
复制标题
内分泌功能障碍对中轴和附肢骨骼的不同影响。
DOI：
10.1172/jci110570
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Riggs,BL
中科院分区：
文献类型：
--
作者：
Seeman,E;Wahner,HW;Offord,KP;Kumar,R;Johnson,WJ;Riggs,BL
在100例不同类型的内分泌功能障碍患者中，我们用单光子吸收法测量了桡骨中段（大于95%的皮质骨）和桡骨远端（75%的皮质骨和25%的松质骨）的骨密度（BMD），并用双光子吸收法测量了腰椎（大于66%的松质骨）的骨密度。每种内分泌疾病的BMD至少在一个部位偏离187名正常受试者的性别特异性年龄回归。对于原发性甲状旁腺功能亢进、皮质醇增多症和甲状腺功能亢进的患者，该偏离为阴性（提示骨丢失），而对于慢性肾衰竭、肢端肥大症和术后甲状旁腺功能减退所致的继发性甲状旁腺功能亢进的患者，该偏离为阳性（提示骨增加）。当所有六种内分泌功能障碍的状态进行了比较，同时进行多变量方差分析，在BMD的变化的配置文件显着不同（P <0.001），表明骨的各种激素的变化的非均匀的反应。当比较三个扫描部位的BMD值时，桡骨中端和远端没有显著差异;然而，两个半径测量值与腰椎有显著差异（P <0.001）。因此，中轴骨的BMD不能可靠地预测，从测量的apapproximular骨骼。我们的结论是，内分泌功能障碍对骨密度的影响是复杂的，是疾病和部位特异性。
In 100 patients with various types of endocrine dysfunction, we measured bone mineral density (BMD) at the midradius (greater than 95% cortical bone) and distal radius (75% cortical and 25% trabecular bone) by single photon absorptiometry and at the lumbar spine (greater than 66% trabecular bone) using the new technique of dual photon absorptiometry. BMD in each endocrine disorder deviated in at least one site from the sex-specific age regression of 187 normal subjects. For patients with primary hyperparathyroidism, hypercortisolism, and hyperthyroidism this deviation was negative (suggesting bone loss), whereas for patients with secondary hyperparathyroidism due to chronic renal failure, acromegaly, and postsurgical hypoparathyroidism it was positive (suggesting bone gain). When all six states of endocrine dysfunction were compared concomitantly by multivariate analysis of variance, the profile of the changes in BMD differed significantly (P less than 0.001), indicating a nonuniform response of bone to the various hormonal alterations. When values for BMD at each of the three scanning sites were compared the midradius and distal radius did not differ significantly; either of the radius measurements, however, differed significantly (P less than 0.001) from the lumbar spine. Thus, the BMD of the axial skeleton cannot be reliably predicted from measurements made in the appendicular skeleton. We conclude that the effects of endocrine dysfunction on bone density are complex and are both disease and site specific.
登录
查看更多内容
胎儿酒精综合症 (FAS)
影响因子：
1.6
作者：
L. Erb;B. Andresen
通讯作者：
B. Andresen
乙醇和乙醛对啮齿动物睾丸睾酮生物合成的影响。
DOI：
10.1016/0006-291x(80)91307-8
发表时间：
1980
影响因子：
3.1
作者：
T. Cicero;R. D. Bell
通讯作者：
R. D. Bell
酒精对成熟雄性大鼠体重增加和下丘脑-垂体-促性腺激素轴的影响。
影响因子：
5.8
作者：
A. Symons;V. Marks
通讯作者：
V. Marks
影响因子：
64.8
作者：
F. Badr;R. S. Badr
通讯作者：
R. S. Badr
营养不足的雄性大鼠青春期时间与体型的关系。
影响因子：
4.8
作者：
A. Glass;J. Anderson;D. Herbert;R. Vigersky
通讯作者：
R. Vigersky