Deconstructing the functional neuroanatomy of the choroid plexus: an ontogenetic perspective for studying neurodevelopmental and neuropsychiatric disorders.
Deconstructing the functional neuroanatomy of the choroid plexus: an ontogenetic perspective for studying neurodevelopmental and neuropsychiatric disorders.
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DOI：
10.1038/s41380-022-01623-6
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发表时间：
2022-09
影响因子：
11
通讯作者：
Woo, Tsung-Ung W.
中科院分区：
文献类型：
--
作者：
Bitanihirwe, Byron K. Y.;Lizano, Paulo;Woo, Tsung-Ung W.
脉络膜丛（CP）是大脑中精细且高度血管化的结构，由密集的开孔毛细血管袢网络组成，有助于脑脊液（CSF）的合成、分泌和循环。这种独特的神经解剖结构是由源自叶状表面突起的蛛网膜绒毛组成的，这些绒毛突出到四个脑室的管腔中，除了作为中枢神经系统代谢废物的“水槽”外，还为脑实质提供重要的营养来源。事实上，CP的功能通常被描述为类似于肝和肾的功能。除了在血液和脑脊液间形成屏障/界面外，CP已被确定为白细胞运输、炎症、认知、昼夜节律和肠脑轴的调节剂。近年来，分子生物学技术和神经影像学的进步以及复杂动物模型的使用，在塑造我们对脑脊液-脑脊液系统如何在大脑发育的关键时期与神经回路成熟相关的变化的理解方面发挥了不可或缺的作用。在这篇文章中，我们提供了一个个体发生的观点，并回顾了实验证据暗示该结构在神经发育和神经精神疾病的病理生理。
The choroid plexus (CP) is a delicate and highly vascularized structure in the brain comprised of a dense network of fenestrated capillary loops that help in the synthesis, secretion and circulation of cerebrospinal fluid (CSF). This unique neuroanatomical structure is comprised of arachnoid villi stemming from frond-like surface projections—that protrude into the lumen of the four cerebral ventricles—providing a key source of nutrients to the brain parenchyma in addition to serving as a ‘sink’ for central nervous system metabolic waste. In fact, the functions of the CP are often described as being analogous to those of the liver and kidney. Beyond forming a barrier/interface between the blood and CSF compartments, the CP has been identified as a modulator of leukocyte trafficking, inflammation, cognition, circadian rhythm and the gut brain-axis. In recent years, advances in molecular biology techniques and neuroimaging along with the use of sophisticated animal models have played an integral role in shaping our understanding of how the CP–CSF system changes in relation to the maturation of neural circuits during critical periods of brain development. In this article we provide an ontogenetic perspective of the CP and review the experimental evidence implicating this structure in the pathophysiology of neurodevelopmental and neuropsychiatric disorders.
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