Green tea and breast cancer.
Green tea and breast cancer.
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绿茶和乳腺癌。
DOI：
10.1002/mnfr.201100006
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发表时间：
2011-06
影响因子：
5.2
通讯作者：
Butler, Lesley M.
中科院分区：
文献类型：
--
作者：
Wu, Anna H.;Butler, Lesley M.
确定可以降低乳腺癌风险的可改变的生活方式因素是研究的重点。尽管绿茶具有巨大的化学预防潜力，动物研究也有令人信服的证据，但它在人类乳腺癌发展中的作用仍不清楚。不确定性的部分原因在于，关于绿茶和乳腺癌的流行病学研究相对较少，而且病例对照研究和前瞻性队列研究的总体结果不一致。此外，绿茶摄入可能影响人类患乳腺癌风险的机制仍未得到充分研究。我们回顾了评估绿茶摄入量与四种生物标志物（性类固醇激素、乳房x线摄影密度、胰岛素样生长因子、脂联素）之间关系的人类研究，这些生物标志物被认为在乳腺癌的发展中很重要。这些生物标志物研究的结果也不确定。讨论了人类研究的局限性和进一步研究的领域。
The identification of modifiable lifestyle factors that could reduce the risk of breast cancer is a research priority. Despite the enormous chemo preventive potential of green tea and compelling evidence from animal studies, its role in breast cancer development in humans is still unclear. Part of the uncertainty is related to the relatively small number of epidemiological studies on green tea and breast cancer and that the overall results from case-control studies and prospective cohort studies are discordant. In addition, the mechanisms by which green tea intake may influence risk of breast cancer in humans remains not well studied. We review the human studies that have evaluated the relationship between green tea intake and four biomarkers (sex steroid hormones, mammographic density, insulin-like growth factor, adiponectin) that are believed to be important in breast cancer development. Results from these biomarker studies are also inconclusive. Limitations of human studies and areas of further investigations are discussed.
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影响因子：
2.6
作者：
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通讯作者：
Brinton, Louise A.
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作者：
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通讯作者：
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作者：
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