Do adipokines underlie the association between known risk factors and breast cancer among a cohort of United States women?
Do adipokines underlie the association between known risk factors and breast cancer among a cohort of United States women?
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DOI：
10.1016/j.canep.2010.05.014
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发表时间：
2010-10
影响因子：
2.6
通讯作者：
Brinton, Louise A.
中科院分区：
文献类型：
--
作者：
Gaudet, Mia M.;Falk, Roni T.;Gierach, Gretchen L.;Lacey, James V., Jr.;Graubard, Barry I.;Dorgan, Joanne F.;Brinton, Louise A.
肥胖是绝经后乳腺癌的一个公认的危险因素，但其关联机制尚不清楚。脂肪细胞衍生的细胞因子样脂肪因子被认为是促成因素。为了评估其与乳腺癌危险因素和乳腺癌风险的关系，我们在美国妇女队列中进行了一项巢式病例对照研究，其中234例绝经后乳腺癌病例和234例对照，前瞻性地收集了1970年代中期获得的血清样本，并随访了长达25年。采用多重免疫分析法测定脂联素、纤溶酶原激活物绝对抑制剂-1 （aPAI-1）和抵抗素。67例患者和67例对照组可获得性激素。在对照组中，我们发现较低的脂联素水平和较高的api -1水平与雌二醇水平升高（Spearman r= - 0.26， p值=0.033;r=0.42, p=0.0003）、性激素结合球蛋白水平降低（r=0.38, p=0.0013; r= - 0.32, p=0.0076）和体重指数（BMI）升高（r= - 0.31, p=<0.0001; r=0.39, p=<0.0001）相关。激素与抵抗素无关。在采血时使用绝经后激素的女性中，aPAI-1水平相对较低（13.7%），高于未使用激素的女性（p=0.0054）。乳腺癌风险与循环水平脂联素（年龄调整线性趋势p= 0.43）、aPAI-1 （p=0.78）或抵抗素（p=0.91）无关。该相关性与BMI、胎次、首次足月分娩年龄、绝经年龄、目前绝经后激素使用情况和循环性类固醇激素无关。此外，脂肪因子的相关性不受BMI的影响（p < 0.05）。缺乏与风险的关联可能是由于实验室分析的测量误差。总之，在前瞻性收集的绝经后妇女血清中，较低水平的脂联素和较高水平的aPAI-1与BMI增加有关，但与乳腺癌风险无关。
Obesity is a well-established risk factor for postmenopausal breast cancer, but mechanisms underlying the association are unclear. Adipocyte-derived, cytokine-like adipokines have been suggested as contributory factors. To evaluate their association with breast cancer risk factors and breast cancer risk, we conducted a nested case-control study of 234 postmenopausal breast cancer cases and 234 controls in a cohort of U.S. women with prospectively-collected serum samples obtained in the mid 1970’s and followed for up to 25 years. Adiponectin, absolute plasminogen activator inhibitor-1 (aPAI-1), and resistin were measured by a multiplex immunoassay. Sex hormones were available for 67 cases and 67 controls. Among controls, we found that lower levels of adiponectin and higher levels of aPAI-1 were correlated with increasing levels of estradiol (Spearman r=−0.26, p-value=0.033; r=0.42, p=0.0003), decreasing levels of sex hormone binding globulin (r=0.38, p=0.0013; r=−0.32, p=0.0076), and increasing body mass index (BMI) (r=−0.31, p=<0.0001; r=0.39, p=<0.0001). Hormones were not associated with resistin. Among the relatively small percentage of women using postmenopausal hormones at the time of blood collection (13.7%), aPAI-1 levels were higher than in nonusers (p=0.0054). Breast cancer risk was not associated with circulating levels of adiponectin (age-adjusted p for linear trend=0.43), aPAI-1 (p=0.78), or resistin (p=0.91). The association was not confounded by BMI, parity, age at first full-term birth, age at menopause, current postmenopausal hormone use, and circulating sex steroid hormones. Furthermore, adipokine associations were not modified by BMI (p>0.05). The lack of association with risk may be due to measurement error of the laboratory assays. In conclusion, lower levels of adiponectin and higher levels of aPAI-1 measured in prospectively-collected serum from postmenopausal women were associated with increasing BMI but not breast cancer risk.
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影响因子：
4.5
作者：
Kang JH;Yu BY;Youn DS
通讯作者：
Youn DS
影响因子：
9.7
作者：
Takahata, Chie;Miyoshi, Yasuo;Noguchi, Shinzaburo
通讯作者：
Noguchi, Shinzaburo
DOI：
10.1016/j.bbrc.2006.04.076
发表时间：
2006-06-23
影响因子：
3.1
作者：
Dieudonne, Marie-Noelle;Bussiere, Marianne;Pecquery, Rene
通讯作者：
Pecquery, Rene
影响因子：
4.8
作者：
Fain, JN;Madan, AK;Bahouth, SW
通讯作者：
Bahouth, SW
影响因子：
10.3
作者：
Look, MP;van Putten, WLJ;Foekens, JA
通讯作者：
Foekens, JA