Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity.
Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity.
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致密的乳房基质组织显示出乳房上皮浓度的大大增加，但其增殖活性没有增加。
DOI：
10.1186/bcr1408
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发表时间：
2006
影响因子：
7.4
通讯作者：
Wu, AH
中科院分区：
文献类型：
--
作者：
Hawes, D;Downey, S;Pearce, CL;Bartow, S;Wan, P;Pike, MC;Wu, AH
乳腺摄影密度增加是乳腺癌的一个重要危险因素。其原因尚不清楚;两个明显的可能性是乳腺X线摄影致密区域的上皮细胞增殖增加和乳腺X线摄影致密乳房的女性乳腺上皮细胞增加。我们通过研究终末导管小叶单位（TDLUs）和导管中的上皮细胞数量及其增殖率来解决这个问题，因为它们与个体女性组织学上定义的局部乳腺密度有关。我们研究了12名接受乳房缩小术的健康女性远离皮下脂肪的深层乳房组织。用细胞增殖标记物MIB 1对每份标本的载玻片进行染色。将每个载玻片分为低、中和高密度结缔组织（CT;与乳腺摄影密度高度相关）区域（组）。在每个区域内，对TDLU和导管中的上皮细胞的数量以及MIB 1阳性的数量进行计数。TDLU中高CT密度区与低CT密度区相比，上皮细胞的相对浓度（RC）为12.3（95%置信区间（CI）10.9至13.8），导管中为34.1（95% CI 26.9至43.2）。中密度区和低密度区之间的差异要小得多：TDLU中RC = 1.4（95% CI 1.2至1.6），导管中RC = 1.9（95% CI 1.5至2.3）。相对有丝分裂率CT高密度区上皮细胞与CT低密度区上皮细胞的比值（RMR; MIB 1阳性）为0.59（95% CI 0.53 - 0.66），TDLU和0.65（95% CI 0.53 - 0.79）导管; TDLU中、低CT密度区的比较值分别为0.58（95%CI 0.48 ~ 0.70）和0.66（95%CI 0.44 ~ 0.97）。乳腺上皮细胞绝大多数集中在CT高密度区。CT高、中密度区的增殖率低于CT低密度区。乳腺癌风险的增加与乳腺摄影密度的增加有关，这可能仅仅是上皮细胞数量增加的反映。为什么上皮细胞集中在高CT密度区域仍有待解释。
Increased mammographic density is a strong risk factor for breast cancer. The reasons for this are not clear; two obvious possibilities are increased epithelial cell proliferation in mammographically dense areas and increased breast epithelium in women with mammographically dense breasts. We addressed this question by studying the number of epithelial cells in terminal duct lobular units (TDLUs) and in ducts, and their proliferation rates, as they related to local breast densities defined histologically within individual women. We studied deep breast tissue away from subcutaneous fat obtained from 12 healthy women undergoing reduction mammoplasty. A slide from each specimen was stained with the cell-proliferation marker MIB1. Each slide was divided into (sets of) areas of low, medium and high density of connective tissue (CT; highly correlated with mammographic densities). Within each of the areas, the numbers of epithelial cells in TDLUs and ducts, and the numbers MIB1 positive, were counted. The relative concentration (RC) of epithelial cells in high compared with low CT density areas was 12.3 (95% confidence interval (CI) 10.9 to 13.8) in TDLUs and 34.1 (95% CI 26.9 to 43.2) in ducts. There was a much smaller difference between medium and low CT density areas: RC = 1.4 (95% CI 1.2 to 1.6) in TDLUs and 1.9 (95% CI 1.5 to 2.3) in ducts. The relative mitotic rate (RMR; MIB1 positive) of epithelial cells in high compared with low CT density areas was 0.59 (95% CI 0.53 to 0.66) in TDLUs and 0.65 (95% CI 0.53 to 0.79) in ducts; the figures for the comparison of medium with low CT density areas were 0.58 (95% CI 0.48 to 0.70) in TDLUs and 0.66 (95% CI 0.44 to 0.97) in ducts. Breast epithelial cells are overwhelmingly concentrated in high CT density areas. Their proliferation rate in areas of high and medium CT density is lower than that in low CT density areas. The increased breast cancer risk associated with increased mammographic densities may simply be a reflection of increased epithelial cell numbers. Why epithelium is concentrated in high CT density areas remains to be explained.
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乳腺癌乳腺癌的发生大大增加了乳房X线X射线密集组织的区域。
影响因子：
7.4
作者：
Ursin, G;Hovanessian-Larsen, L;Parisky, YR;Pike, MC;Wu, AH
通讯作者：
Wu, AH
影响因子：
3.8
作者：
Li, T;Sun, LM;Boyd, N
通讯作者：
Boyd, N
DOI：
10.1186/bcr622
发表时间：
2003
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Alowami S;Troup S;Al-Haddad S;Kirkpatrick I;Watson PH
通讯作者：
Watson PH
影响因子：
5.8
作者：
Hargreaves, DF;Potten, CS;Bundred, NJ
通讯作者：
Bundred, NJ
影响因子：
5.5
作者：
SAFTLAS, AF;SZKLO, M
通讯作者：
SZKLO, M