Bioimaging of hypochlorous acid using a near-infrared fluorescent probe derived from rhodamine dye with a large Stokes shift
Bioimaging of hypochlorous acid using a near-infrared fluorescent probe derived from rhodamine dye with a large Stokes shift
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使用源自具有大斯托克斯位移的罗丹明染料的近红外荧光探针对次氯酸进行生物成像
DOI：
10.1016/j.snb.2022.131868
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Chunya Li
中科院分区：
文献类型：
--
作者：
Meng He;Miantai Ye;Bo Li;Tsunghsueh Wu;Chunfeng Lu;Pan Liu;Huiyue Li;Xingyu Zhou;Yanying Wang;Tao Liang;Haiyan Li;Chunya Li
Hypochlorous acid (HClO) is a bioactive molecule that bears an important function in various physiological and pathological processes such as cell signal transduction, pathogen invasion, and redox balance regulation. The near-infrared (NIR) fluorescent probe with a large Stokes shift for bioimaging of HClO is envisioned to outperform other fluorescence probes with following advantages: greater penetration depth, smaller overlap between emission and absorption spectra, and greater reduction in false results caused by the excitation light and the scattered light, aiming to achieve selective and sensitive bioimaging of HClOin vivo. Herein, a NIR fluorescent probe,TJM, was synthesized by modifying the structure of rhodamine dye to make it water soluble and biocompatible for living cells. Under being excited at 585 nm,TJMexhibits an emission peak at 730 nm with a large Stokes shift of 145 nm.TJMalso provides a fast NIR fluorescent response to HClO with excellent selectivity, high sensitivity, and low detection limit (0.11 μM). The fluorescence intensity ofTJMis triggered by HClO based on HClO-induced oxidization of dibenzoyl hydrazine to dibenzoyl diimide, allowing imaging of HClO in living cells, zebrafish, and different disease mice models.TJMhas been demonstrated a suitable NIR probe for imaging endogenous HClO in biological systems.
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生物成像近红外荧光探针开发的一般策略。
DOI：
10.1002/anie.201710688
发表时间：
2017-12-22
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Chen W;Xu S;Day JJ;Wang D;Xian M
通讯作者：
Xian M
DOI：
10.1038/nri3423
发表时间：
2013-05
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1002/chin.199744337
发表时间：
1997-10
期刊：
ChemInform
影响因子：
--
作者：
A. P. D. Silva;H. Gunaratne;T. Gunnlaugsson;Allen J. M. Huxley;C. McCoy;J. Rademacher;Terence E. Rice
通讯作者：
A. P. D. Silva;H. Gunaratne;T. Gunnlaugsson;Allen J. M. Huxley;C. McCoy;J. Rademacher;Terence E. Rice
用于生物成像的近红外荧光探针的独特方法，对比度显着增强
影响因子：
8.4
作者：
Gong YJ;Zhang XB;Mao GJ;Su L;Meng HM;Tan W;Feng S;Zhang G
通讯作者：
Zhang G
通过引入交替振动结构来增加斯托克斯位移的通用方法
影响因子：
15
作者：
Ren, Tian-Bing;Xu, Wang;Zhang, Xiao-Bing
通讯作者：
Zhang, Xiao-Bing