Anterior insular cortex anticipates impending stimulus significance.
Anterior insular cortex anticipates impending stimulus significance.
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DOI：
10.1016/j.neuroimage.2008.12.070
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发表时间：
2009-04-15
期刊：
影响因子：
5.7
通讯作者：
Paulus MP
中科院分区：
文献类型：
--
作者：
Lovero KL;Simmons AN;Aron JL;Paulus MP
触摸是日常互动的基本但复杂的元素，通过内感受处理影响一个人的感官和情感体验。岛叶皮层是参与内感受的神经过程的组成部分，即通过对内部身体状态的感知来产生“情感时刻”。在这里，我们研究的贡献，岛叶皮层的不同部分的代表性的情感和感官方面的触摸。为此，受试者在功能性MRI期间被给予触摸的提示应用。我们发现，刺激相关的激活发生在中后丘脑，而预期相关的激活主要出现在前丘脑。此外，在预期过程中，前额叶的激活程度与刺激处理过程中后额叶和尾状核的激活程度相关。最后，在预期过程中，前额叶的激活程度也与触摸的强度有关。总的来说，这些结果与前额叶为触觉的感觉和情感影响做准备的假设是一致的。这种准备功能对于理解焦虑和成瘾障碍具有重要意义，因为预期处理功能障碍是精神病理学的基本组成部分。
Touch is a fundamental, but complex, element of everyday interaction that impacts one’s sensory and affective experience via interoceptive processing. The insular cortex is an integral component of the neural processes involved in interoception, i.e. the generation of an “emotional moment in time” through the sensing of the internal body state. Here, we examine the contribution of different parts of the insular cortex in the representation of both affective and sensory aspects of touch. To that end, subjects were administered a cued application of touch during functional MRI. We find that stimulus-related activation occurs in the mid-to-posterior insula, whereas anticipatory related activation is seen mostly in anterior insula. Moreover, the degree of activation in anterior insula during anticipation is correlated with the degree of activation in the posterior insula and caudate during stimulus processing. Finally, the degree of activation in the anterior insula during anticipation is also correlated with experienced intensity of the touch. Taken together, these results are consistent with the hypothesis that the anterior insula is preparing for the sensory and affective impact of touch. This preparatory function has important implications for the understanding of both anxiety and addictive disorders because dysfunctions in anticipatory processing are a fundamental part of the psychopathology.
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