Metamorphopsia associated with central retinal vein occlusion.
Metamorphopsia associated with central retinal vein occlusion.
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DOI：
10.1371/journal.pone.0186737
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Tsujikawa A
中科院分区：
文献类型：
--
作者：
Manabe K;Osaka R;Nakano Y;Takasago Y;Fujita T;Shiragami C;Hirooka K;Muraoka Y;Tsujikawa A
这项前瞻性研究旨在研究视网膜中央静脉阻塞（CRVO）患者的视物变形，包括28只单侧CRVO患者，急性期有黄斑水肿（ME）。用抗血管内皮生长因子药物治疗ME。在基线和治疗开始后1个月和6个月，使用M-CHARTS进行视物变形的定量测量，并通过光学相干断层扫描检查视网膜形态学变化。基线时，在M-CHARTS上检测到14只（50.0%）眼睛的视物变形。平均M-CHARTS评分为0.37 ± 0.53。在开始治疗后1个月和6个月，ME基本消退，视力显著恢复。相比之下，6个月时仍有16只眼检测到视物变形; 1个月时的平均M-CHARTS评分为0.29 ± 0.37，6个月时为0.32 ± 0.38，与基线相比无显著改善（分别为p = 0.580和p = 0.604）。尽管6个月时的M-CHARTS评分与基线M-CHARTS评分相关（p = 0.004），但与基线时的形态学参数无任何相关性。然而，6个月时的M-CHARTS评分与1个月时的视网膜中央凹感光状态、浆液性脱离高度和视网膜旁增厚显著相关。与CRVO相关的视物变形可以使用M-CHARTS进行量化，并且通常与抗血管内皮生长因子药物治疗后视力恢复和ME消退形成对比。
This prospective study aimed to investigate metamorphopsia in eyes with central retinal vein occlusion (CRVO) and included 28 eyes (28 patients) with unilateral CRVO that had macular edema (ME) in the acute phase. The ME was treated with anti-vascular endothelial growth factor agents. At baseline and at 1 and 6 months after initiation of treatment, quantitative measurements of metamorphopsia were performed using M-CHARTS and the retinal morphologic changes were examined by optical coherence tomography. At baseline, metamorphopsia was detected on M-CHARTS in 14 (50.0%) eyes. The mean M-CHARTS score was 0.37 ± 0.53. At 1 month and 6 months after initiation of treatment, there was substantial resolution of ME and significant recovery of visual acuity. In contrast, metamorphopsia was still detected in 16 eyes at 6 months; the mean M-CHARTS scores were 0.29 ± 0.37 at 1 month and 0.32 ± 0.38 at 6 months, and had not significantly improved from baseline (p = 0.580, and p = 0.604, respectively). Although the M-CHARTS score at 6 months was associated with the baseline M-CHARTS score (p = 0.004), it did not have any associations with morphologic parameters at baseline. However, the M-CHARTS score at 6 months was significantly associated with foveal photoreceptor status, height of serous detachment, and parafoveal thickening at 1 month. Metamorphopsia associated with CRVO could be quantified using M-CHARTS, and often persisted in contrast with the recovery of visual acuity and resolution of ME after treatment with anti-vascular endothelial growth factor agents.
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影响因子：
3.7
作者：
Manabe K;Tsujikawa A;Osaka R;Nakano Y;Fujita T;Shiragami C;Hirooka K;Uji A;Muraoka Y
通讯作者：
Muraoka Y
影响因子：
4.2
作者：
Nitta, Eri;Shiraga, Fumio;Fujiwara, Atsushi
通讯作者：
Fujiwara, Atsushi
影响因子：
2.4
作者：
Ota, Masafumi;Tsujikawa, Akitaka;Yoshimura, Nagahisa
通讯作者：
Yoshimura, Nagahisa
DOI：
10.1159/000320076
发表时间：
2010-01-01
期刊：
MACULAR EDEMA: A PRACTICAL APPROACH
影响因子：
--
作者：
Jonas, Jost;Paques, Michel;Glacet-Bernard, Agnes
通讯作者：
Glacet-Bernard, Agnes
DOI：
10.1007/s00417-016-3382-2
发表时间：
2016-11-01
影响因子：
2.7
作者：
Murakami, Tomoya;Okamoto, Fumiki;Oshika, Tetsuro
通讯作者：
Oshika, Tetsuro