Ovarian volume partially explains associations of phthalate biomarkers with anti-Müllerian hormone and estradiol in midlife women.
Ovarian volume partially explains associations of phthalate biomarkers with anti-Müllerian hormone and estradiol in midlife women.
复制标题
DOI：
10.1016/j.envint.2023.107771
复制
发表时间：
2023-02
影响因子：
11.8
通讯作者：
Strakovsky, Rita S.
中科院分区：
文献类型：
--
作者：
Cinzori, Maria E.;Pacyga, Diana C.;Babayev, Elnur;Duncan, Francesca E.;Li, Zhong;Williams, Paige L.;Flaws, Jodi A.;Strakovsky, Rita S.
Women are ubiquitously exposed to endocrine disruptors, including phthalates. Ovarian follicles undergoing folliculogenesis (indirectly measured by ovarian volume) produce anti-Müllerian hormone (AMH) and estradiol (E2). We evaluated associations of phthalates with ovarian volume to assess whether this explained prior positive associations of phthalates with AMH and E2. Women ages 45–54 years (n = 614) had transvaginal ultrasounds of right/left ovaries to calculate mean ovarian volume. Women provided up-to-four urine and blood samples for quantifying AMH (first serum sample), E2 (all serum samples), and nine phthalate metabolites (from pooled urine, representing six parent phthalates). Multivariable linear or logistic regression models (for individual phthalate biomarkers), as well as weighted quantile sum (WQS) regression (for mixture analyses) evaluated associations of phthalate biomarkers with ovarian volume. Using cross-sectional mediation analysis, we assessed whether associations of phthalates with ovarian volume partially explained those of phthalates with AMH or E2. Most women were non-Hispanic White (68%) and pre-menopausal (67%) with higher urinary phthalate metabolite concentrations than U.S. women. In single-pollutant models, 10% increases in mono(3-earboxypropyl) phthalate (MCPP) and monobenzyl phthalate (MBzP) were associated with 0.44% (95% CI: −0.02%, 0.91%) and 0.62% (95% CI: 0.02%, 1.23%) larger ovarian volumes, respectively. As a cumulative mixture, 10% increases in the phthalate mixture were associated with 2.89% larger ovarian volume (95%CI: 0.27, 5.59) with MCPP (35%) and MBzP (41%) identified as major contributors. Higher ovarian volume due to a 10% increase in MBzP (indirect effect OR: 1.004; 95% CI: 1.00, 1.01) explained 16% of the positive association between MBzP and higher AMH, whereas higher ovarian volume due to a 10% increase in MCPP (indirect effect %Δ: 0.11; 95% CI: −0.01, 0.22) explained 23% of the positive association between MCPP and E2. In this cross-sectional study, phthalates were associated with increased ovarian volume, with implications for midlife hormone production.
登录
查看更多内容
影响因子：
24
作者：
Gadde KM;Martin CK;Berthoud HR;Heymsfield SB
通讯作者：
Heymsfield SB
影响因子：
8.3
作者：
Haggerty DK;Flaws JA;Li Z;Strakovsky RS
通讯作者：
Strakovsky RS
影响因子：
8.8
作者：
Al-Saleh, Iman;Coskun, Serdar;Al-Hassan, Saad
通讯作者：
Al-Hassan, Saad
影响因子：
5.8
作者：
Al-Saleh, Iman;Elkhatib, Rola
通讯作者：
Elkhatib, Rola
影响因子：
5.8
作者：
Bao, AM;Liu, RY;Zhou, JN
通讯作者：
Zhou, JN