Telocytes in liver: electron microscopic and immunofluorescent evidence.

Telocytes in liver: electron microscopic and immunofluorescent evidence.
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肝脏中的特洛细胞:电子显微镜和免疫荧光证据

DOI:
10.1111/jcmm.12195
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发表时间:
2013-12
影响因子:
5.3
通讯作者:
Yang C
Yang C
中科院分区:
医学2区
文献类型:
--
作者:
Xiao J;Wang F;Liu Z;Yang C

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肝间质细胞在调节肝脏的基本生物过程中发挥着至关重要的作用。特洛细胞 (TC) 是 Popescu 及其同事首先发现的一种新型间质细胞,已在许多组织和器官中发现,但尚未在肝脏中发现(请访问 http://www.telologies.com)。我们使用透射电子显微镜和免疫荧光(CD34 和 c-kit/CD117、波形蛋白、PDGF 受体-α 或 β 双标记)为小鼠肝脏中 TC 的存在提供证据。发现 TC 在肝脏中的分布在四个肝叶中具有相似的密度。总之,我们在这里展示了小鼠肝脏中 TC 的存在。 TC 在控制肝脏稳态和再生中的可能作用仍有待确定,尤其是在 TC 与肝假定干(祖)细胞之间发现密切的特殊关系时更是如此。
Hepatic interstitial cells play a vital role in regulating essential biological processes of the liver. Telocytes (TCs), a novel type of interstitial cells firstly identified by Popescu and his coworkers, have been reported in many tissues and organs, but not yet in liver (go to http://www.telocytes.com). We used transmission electron microscopy and immunofluorescence (double labelling for CD34 and c‐kit/CD117, or vimentin, or PDGF Receptor‐α, or β) to provide evidence for the existence of TCs in mice liver. The distribution of TCs in liver was found to be of similar density in the four hepatic lobes. In conclusion, here we show the presence of TCs in mice liver. It remains to be determined the possible roles of TCs in the control of liver homeostasis and regeneration, the more so as a close special relationship was found between TCs and hepatic putative stem (progenitor) cells.
DOI: 10.1111/j.1582-4934.2012.01580.x
发表时间: 2012-07
影响因子: 5.3
作者:
Ceafalan L;Gherghiceanu M;Popescu LM;Simionescu O
通讯作者: Simionescu O
DOI: 10.1111/jcmm.12111
发表时间: 2013-08
影响因子: 5.3
作者:
Luesma MJ;Gherghiceanu M;Popescu LM
通讯作者: Popescu LM
DOI: 10.1111/j.1582-4934.2010.01207.x
发表时间: 2011-01
影响因子: 5.3
作者:
Cantarero Carmona I;Luesma Bartolomé MJ;Junquera Escribano C
通讯作者: Junquera Escribano C
DOI: 10.1111/j.1582-4934.2012.01646.x
发表时间: 2013-01
影响因子: 5.3
作者:
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DOI: 10.1530/rep-12-0369
发表时间: 2013-04
期刊: Reproduction (Cambridge, England)
影响因子: --
作者:
Cretoiu SM;Cretoiu D;Marin A;Radu BM;Popescu LM
通讯作者: Popescu LM