A Critical Review and Scientific Prospective on Contraceptive Therapeutics from Ayurveda and Allied Ancient Knowledge.
A Critical Review and Scientific Prospective on Contraceptive Therapeutics from Ayurveda and Allied Ancient Knowledge.
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DOI：
10.3389/fphar.2021.629591
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发表时间：
2021
影响因子：
5.6
通讯作者：
Deshpande M
中科院分区：
文献类型：
--
作者：
Bhatt N;Deshpande M
众所周知，常用的合成或处方激素类药物会干扰内分泌系统，并可能对人体的生殖、神经、发育和代谢产生不利影响。这些也可能产生不良影响，如多囊卵巢疾病、子宫内膜异位症、青春期提前、不育或性腺毒性、睾丸生殖细胞癌、乳腺癌或前列腺癌、大脑发育问题，甚至出生缺陷。在全球范围内，人们对促进生殖健康的天然产品重新产生了兴趣，这为开发新的避孕药具提供了机会。寻找替代的、更安全的避孕产品或天然来源的药物具有科学意义。阿育吠陀经典文献提供了关于生殖功能和治疗方法的知识和信息，包括那些增强和限制男性和女性生育能力的知识和信息。回顾古代、中世纪和近代——包括提供方法和大量植物、矿物或动物来源的配方和药物的色情文本——声称具有绝育、避孕、堕胎和相关特性。其中很少有已知有毒的，也很少有不常见的。然而，由于与消费者依从性和标准化限制以及缺乏适当的验证方式有关的问题，大多数配方、成分或给药方式仍然无人注意。已经研究了其中一些成分的植物成分和各种药理活性。努力使几种经典剂型标准化，并尝试适应现代技术。配方、成分及其与已知成分、药理学、生物学和毒性研究相关的特性的清单已在一系列表格中提供。对选定的配方和成分可能的有效性和安全性进行了检查。考虑了基于结合生物技术进步的新药物输送系统的建议，为避孕新疗法提供了前景。阿育吠陀是建立在生物实体的整体范式，而不是有限的性腺功能。对一些精心挑选的可能性进行了图解。自然避孕疗法标准化和民族药理学验证的新方法可能为满足未满足的避孕需求提供新的机制和方式和治疗机会。
Commonly used synthetic or prescribed hormonal drugs are known to interfere with the endocrine system and may have adverse reproductive, neurological, developmental, and metabolic effects in the body. These may also produce adverse effects such as polycystic ovarian disorder, endometriosis, early puberty, infertility or toxicity to gonads, testicular germ cell cancer, breast or prostate cancer, brain developmental problems, and even birth defects. Globally, the emergence of renewed interest in natural products for reproductive health is on the rise, which offers opportunities for new contraceptive developments. The search for alternate, safer contraceptive products or agents of natural origin is of scientific interest. Ayurvedic classical texts offer knowledge and information about the reproductive function and therapeutics including those for enhancement and limiting male and female fertility. Review of ancient, medieval, and recent—including texts on erotica that provide information on approaches and large numbers of formulations and drugs of plant, mineral or animal origin—claimed to have sterilizing, contraceptive, abortifacient, and related properties is presented. Few among these are known to be toxic and few are not so common. However, most of the formulations, ingredients, or modes of administration have remained unattended to, due to issues related to consumer compliance and limitations of standardization and lack of appropriate validation modalities. Several of these ingredients have been studied for their phytoconstituents and for the variety of pharmacological activities. Efforts to standardize several classical dosage forms and attempts to adapt to modern technologies have been made. List of formulations, ingredients, and their properties linked with known constituents, pharmacological, biological, and toxicity studies have been provided in a series of tables. The possible effectiveness and safety of selected formulations and ingredients have been examined. Suggestions based on new drug delivery systems integrated with advances in biotechnology, to provide prospects for new therapeutics for contraception, have been considered. Ayurveda is built on a holistic paradigm of biological entity rather than limited gonadal functions. Graphic presentation of a few carefully chosen possibilities has been depicted. New approaches to standardization and ethnopharmacological validation of natural contraceptive therapeutics may offer novel mechanisms and modalities and therapeutic opportunities to satisfy unmet needs of contraception.
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影响因子：
5.4
作者：
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通讯作者：
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