Neural representation of newly instructed rule identities during early implementation trials
Neural representation of newly instructed rule identities during early implementation trials
复制标题
早期实施试验期间新指令规则身份的神经表示
作者：
Hannes Ruge;Theo A J Schäfer;Katharina Zwosta;Holger Mohr;U. Wolfensteller
通过遵循明确的指示，人类可以立即掌握他们以前从未执行过的任务的窍门。我们使用了一种专门校准的多变量分析技术来揭示在最初几次执行任意规则期间难以捉摸的表征状态，例如在第一次指令后“要喝咖啡，请按红色按钮”。腹外侧前额叶皮层 (VLPFC) 内的分布式活动模式表明存在特定于个体刺激-反应 (S-R) 规则身份的神经表征，特别是在需要记住指导的 S-R 规则才能正确执行的情况下。从第一次实施试验开始，特定于身份的表示就可以被检测到，并且在早期实施试验中继续存在。通过 VLPFC 和前纹状体之间不断加强的合作，新型规则表征的应用日益流畅。这些发现为有关前额叶皮层如何通过在首次实施期间对新指示的个体规则身份进行临时编码来支持行为灵活性的代表性理论提供了信息。
By following explicit instructions, humans instantaneously get the hang of tasks they have never performed before. We used a specially calibrated multivariate analysis technique to uncover the elusive representational states during the first few implementations of arbitrary rules such as ‘for coffee, press red button’ following their first-time instruction. Distributed activity patterns within the ventrolateral prefrontal cortex (VLPFC) indicated the presence of neural representations specific of individual stimulus-response (S-R) rule identities, preferentially for conditions requiring the memorization of instructed S-R rules for correct performance. Identity-specific representations were detectable starting from the first implementation trial and continued to be present across early implementation trials. The increasingly fluent application of novel rule representations was channelled through increasing cooperation between VLPFC and anterior striatum. These findings inform representational theories on how the prefrontal cortex supports behavioral flexibility specifically by enabling the ad-hoc coding of newly instructed individual rule identities during their first-time implementation.
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DOI：
10.3758/s13415-014-0325-4
发表时间：
2015-06
期刊：
Cognitive, affective & behavioral neuroscience
影响因子：
--
作者：
Ruge H;Wolfensteller U
通讯作者：
Wolfensteller U
影响因子：
2.9
作者：
Cole MW;Etzel JA;Zacks JM;Schneider W;Braver TS
通讯作者：
Braver TS
影响因子：
3.7
作者：
Cole, Michael W.;Ito, Takuya;Braver, Todd S.
通讯作者：
Braver, Todd S.
影响因子：
25
作者：
Yang, Guangyu Robert;Joglekar, Madhura R.;Wang, Xiao-Jing
通讯作者：
Wang, Xiao-Jing
影响因子：
16.6
作者：
Pauli, Wolfgang M.;Gentile, Giovanni;O'Doherty, John P.
通讯作者：
O'Doherty, John P.