Spatial modulation of dark versus bright stimulus responses in the mouse visual system.
Spatial modulation of dark versus bright stimulus responses in the mouse visual system.
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DOI：
10.1016/j.cub.2021.06.094
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发表时间：
2021-09-27
期刊：
影响因子：
--
通讯作者：
Haider B
中科院分区：
文献类型：
--
作者：
Williams B;Del Rosario J;Muzzu T;Peelman K;Coletta S;Bichler EK;Speed A;Meyer-Baese L;Saleem AB;Haider B
视觉系统的基本任务是用动作电位（ON和OFF响应）对亮度的增加和减少做出响应。在猫和灵长类动物的初级视觉皮层（V1）中，OFF反应比ON反应更强，更快，更突出，但在雪貂和小鼠中，ON反应可能比OFF反应更强，更弱或平衡。这些差异可能来自物种，实验技术或刺激特性的差异，特别是在视野中的retinotopic位置，已经推测;然而，retinotopy的ON/OFF优势的作用还没有系统地测试跨多个尺度的物种内的神经活动。在这里，我们测量了关与开的反应，在大部分的视觉空间与硅探针和全细胞膜片钳记录在小鼠V1和外侧膝状体核（LGN）。我们发现，OFF反应占主导地位的中央视野，而ON和OFF反应更平衡的周边。这些发现在V1的局部场电位（LFP）、尖峰和阈下膜电位中是一致的，并且与LGN中ON和OFF响应的空间偏差一致。我们的研究结果表明，视网膜病变可能提供了一个共同的组织原则，在哺乳动物视觉系统的OFF与ON处理的空间调制。视觉系统神经元对明亮和黑暗刺激（ON和OFF反应）都有反应;目前还不清楚哪种反应主导哺乳动物的视觉。威廉姆斯等人测量了清醒小鼠视觉皮层和丘脑的这些反应，发现中央视野中的刺激比远周边的刺激驱动更强的OFF反应。
A fundamental task of the visual system is to respond to both increases and decreases of luminance with action potentials (ON and OFF responses). OFF responses are stronger, faster, and more salient than ON responses in primary visual cortex (V1) of both cats and primates, but in ferrets and mice ON responses can be stronger, weaker, or balanced in comparison to OFF responses. These discrepancies could arise from differences in species, experimental techniques, or stimulus properties, particularly retinotopic location in the visual field, as has been speculated; however, the role of retinotopy for ON/OFF dominance has not been systematically tested across multiple scales of neural activity within species. Here, we measured OFF versus ON responses across large portions of visual space with silicon probe and whole-cell patch-clamp recordings in mouse V1 and lateral geniculate nucleus (LGN). We found that OFF responses dominated in the central visual field, whereas ON and OFF responses were more balanced in the periphery. These findings were consistent across local field potential (LFP), spikes, and subthreshold membrane potential in V1, and were aligned with spatial biases in ON and OFF responses in LGN. Our findings reveal that retinotopy may provide a common organizing principle for spatial modulation of OFF versus ON processing in mammalian visual systems. Visual system neurons respond to both bright and dark stimuli (ON and OFF responses); it remains unclear which of these dominate mammalian vision. Williams et al. measure these responses across visual cortex and thalamus in awake mice, and find that stimuli in the central visual field drive stronger OFF responses than stimuli in the far periphery.
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