Gonadal steroid hormone receptors in the medial amygdala contribute to experience-dependent changes in stress vulnerability.
Gonadal steroid hormone receptors in the medial amygdala contribute to experience-dependent changes in stress vulnerability.
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DOI：
10.1016/j.psyneuen.2021.105249
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发表时间：
2021-07
影响因子：
3.7
通讯作者：
Adler SG
中科院分区：
文献类型：
--
作者：
Cooper MA;Clinard CT;Dulka BN;Grizzell JA;Loewen AL;Campbell AV;Adler SG
社会经验可以产生神经可塑性，从而改变个体对压力的反应。赢得攻击会改变动物对未来挑战的反应，并导致血浆睾酮浓度和社会行为神经网络中雄激素受体（AR）表达的增加。在这个项目中，我们的目标是确定神经内分泌机制，该机制解释了在两周内建立优势关系后压力相关行为的变化。我们使用了一个叙利亚仓鼠模型，其中急性社会失败压力增加了雄性条件失败测试和雌性社会回避测试中的焦虑样反应。首先，在雄性仓鼠建立优势关系期间，我们每天通过腹腔注射氟他胺（一种AR拮抗剂）。我们发现，AR的药物阻断阻止了优势雄性条件失败的减少，并阻断了AR在杏仁核后背部内侧（MePD）和后腹侧内侧杏仁核（MePV）的上调，但在腹侧外侧隔中没有。接下来，我们在男性急性社会失败压力或条件失败测试之前，将氟他胺施用于内侧杏仁核（MeP）的后侧。我们发现，在社交失败之前，而不是在测试之前，在MeP中阻断AR的药物会增加优势雄性的条件失败反应，而不会改变下属的行为。最后，我们开发了一种方法来建立雌性仓鼠的优势关系，并研究了血浆类固醇激素浓度、雌激素受体α (ERα)免疫反应性和失败诱导的社会回避的状态依赖性变化。我们发现，优势雌性仓鼠在社交失败暴露的情况下表现出社交回避的减少，以及med中ERα表达的增加，但血浆类固醇激素浓度没有状态依赖性的变化。总的来说，这些发现表明，实现和维持稳定的社会优势导致MeP中性别特异性的神经可塑性，这是应激易感性状态依赖性变化的基础。
Social experience can generate neural plasticity that changes how individuals respond to stress. Winning aggressive encounters alters how animals respond to future challenges and leads to increased plasma testosterone concentrations and androgen receptor (AR) expression in the social behavior neural network. In this project, our aim was to identify neuroendocrine mechanisms that account for changes in stress-related behavior following the establishment of dominance relationships over a two-week period. We used a Syrian hamster model in which acute social defeat stress increases anxiety-like responses in a conditioned defeat test in males and in a social avoidance test in females. First, we administered flutamide, an AR antagonist, via intraperitoneal injections daily during the establishment of dominance relationships in male hamsters. We found that pharmacological blockade of AR prevented a reduction in conditioned defeat in dominant males and blocked an upregulation of AR in the posterior dorsal medial amygdala (MePD) and posterior ventral medial amygdala (MePV), but not in the ventral lateral septum. Next, we administered flutamide into the posterior aspects of the medial amygdala (MeP) prior to acute social defeat stress or prior to conditioned defeat testing in males. We found that pharmacological blockade of AR in the MeP prior to social defeat, but not prior to testing, increased the conditioned defeat response in dominant males and did not alter behavior in subordinates. Finally, we developed a procedure to establish dominance relationships in female hamsters and investigated status-dependent changes in plasma steroid hormone concentrations, estrogen receptor alpha (ERα) immunoreactivity, and defeat-induced social avoidance. We found that dominant female hamsters showed reduced social avoidance regardless of social defeat exposure as well as increased ERα expression in the MePD, but no status-dependent changes in the concentration of plasma steroid hormones. Overall, these findings suggest that achieving and maintaining stable social dominance leads to sex-specific neural plasticity in the MeP that underlies status-dependent changes in stress vulnerability.
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影响因子：
2.9
作者：
Cooper, Matthew A.;Seddighi, Sahba;Clinard, Catherine T.
通讯作者：
Clinard, Catherine T.
影响因子：
4.8
作者：
Fuxjager, Matthew J.;Oyegbile, Temitayo O.;Marler, Catherine A.
通讯作者：
Marler, Catherine A.
影响因子：
8.2
作者：
Bartolomucci, A;Palanza, P;Parmigiani, S
通讯作者：
Parmigiani, S
影响因子：
2.9
作者：
Bartolomucci, A;Palanza, P;Parmigiani, S
通讯作者：
Parmigiani, S
DOI：
10.1073/pnas.1001394107
发表时间：
2010-07-06
影响因子：
11.1
作者：
Fuxjager, Matthew J.;Forbes-Lorman, Robin M.;Marler, Catherine A.
通讯作者：
Marler, Catherine A.