Tracing of the fecal microbiota of commercial pigs at five growth stages from birth to shipment.
Tracing of the fecal microbiota of commercial pigs at five growth stages from birth to shipment.
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DOI：
10.1038/s41598-018-24508-7
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发表时间：
2018-04-16
影响因子：
4.6
通讯作者：
Choi YJ
中科院分区：
文献类型：
--
作者：
Han GG;Lee JY;Jin GD;Park J;Choi YH;Kang SK;Chae BJ;Kim EB;Choi YJ
肠道微生物群影响宿主动物的各种生理特征，如大脑发育、肥胖、年龄和免疫系统。在养猪业中，了解肠道微生物群与生长阶段的关系至关重要，因为生长阶段直接关系到猪的饲养系统，因此我们研究了32头健康猪在10、21、63、93和147日龄的5头母猪的肠道微生物群。随着猪的生长，肠道微生物群发生了变化，并被分为三个不同的群。在不同的生长阶段，几个门和属的相对丰度存在显著差异。我们观察到肠道微生物群在每个生长阶段的共现模式。此外，我们预测了肠道微生物群的功能，并证实了几种KEGG通路在生长阶段之间存在显著差异。我们还探讨了肠道菌群与先天因素（如母体效应和性别）的关系。仔猪幼年时，先天因素会影响肠道菌群的构建，但随着生长，这种倾向逐渐消失。我们的研究结果拓宽了对微生物生态学的认识，并将为研究养猪业中宿主-微生物相互作用提供参考。
The intestinal microbiota affect various physiological traits of host animals such as brain development, obesity, age, and the immune system. In the swine industry, understanding the relationship between intestinal microbiota and growth stage is essential because growth stage is directly related to the feeding system of pigs, thus we studied the intestinal microbiota of 32 healthy pigs across five sows at 10, 21, 63, 93, and 147 d of ages. The intestinal microbiota were altered with growth of pigs and were separated into three distinct clusters. The relative abundance of several phyla and genera were significantly different between growth stages. We observed co-occurrence pattern of the intestinal microbiota at each growth stage. In addition, we predicted the functions of the intestinal microbiota and confirmed that several KEGG pathways were significantly different between growth stages. We also explored the relationship between the intestinal microbiota and innate factors such as the maternal effect and gender. When pigs were young, innate factors affected on construction of intestinal microbiota, however this tendency was disappeared with growth. Our findings broaden the understanding of microbial ecology, and the results will be used as a reference for investigating host-microbe interactions in the swine industry.
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断奶过渡期间商品仔猪肠道微生物群的成熟发展
影响因子：
5.2
作者：
Chen L;Xu Y;Chen X;Fang C;Zhao L;Chen F
通讯作者：
Chen F
影响因子：
--
作者：
Han GG;Kim EB;Lee J;Lee JY;Jin G;Park J;Huh CS;Kwon IK;Kil DY;Choi YJ;Kong C
通讯作者：
Kong C
DOI：
10.1126/science.1198719
发表时间：
2011-05-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Muegge BD;Kuczynski J;Knights D;Clemente JC;González A;Fontana L;Henrissat B;Knight R;Gordon JI
通讯作者：
Gordon JI
影响因子：
3.3
作者：
Mach, Nuria;Berri, Mustapha;Lepage, Patricia
通讯作者：
Lepage, Patricia
DOI：
10.1073/pnas.1219451110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Everard, Amandine;Belzer, Clara;Cani, Patrice D.
通讯作者：
Cani, Patrice D.