Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.
Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.
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DOI：
10.1371/journal.pone.0111562
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Xiang YT
中科院分区：
文献类型：
--
作者：
Zhou FC;Hou WM;Wang CY;Ungvari GS;Chiu HF;Correll CU;Shum DH;Man D;Liu DT;Xiang YT
我们的目的是调查前瞻性记忆和它的社会人口统计学和神经认知相关性的非精神病，精神分裂症患者的一级亲属（FDR）相比，首发精神分裂症（FES）患者和健康对照（HC）。47例FES患者，50例慢性精神分裂症患者（与FES组无关）的非精神病FDR（23名子女和27名同胞）和51例HC进行了研究。采用中文版的剑桥前瞻记忆测验（C-CAMPROMPT）测量基于时间的前瞻记忆（TBPM）和基于事件的前瞻记忆（EBPM）的成绩。其他认知功能（包括各自的记忆和执行功能）采用标准化测试进行评估。在控制了包括年龄、性别和教育水平在内的基本人口统计学特征后，FDR、FES和HC之间在TBPM（F（2，142）= 10.4，p<0.001）和EBPM（F（2，142）= 10.8，p<0.001）方面存在显著差异。 多元线性回归分析显示，霍普金斯言语学习测验（HVLT-R）和Stroop词色测验（SWCT）的低分与TBPM损伤有关，而教育程度低和CTT-2的高分与EBPM损伤有关。FDR与精神分裂症患者共享相似但减弱的前瞻性记忆障碍，这表明前瞻性记忆障碍可能代表精神分裂症的内表型。
We aimed at investigating prospective memory and its socio-demographic and neurocognitive correlates in non-psychotic, first-degree relatives (FDRs) of patients with schizophrenia compared to patients with first episode schizophrenia (FES), and healthy controls (HCs). Forty-seven FES patients, 50 non-psychotic FDRs (23 offspring and 27 siblings) of patients with chronic schizophrenia (unrelated to the FES group) and 51 HCs were studied. The Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT) was used to measure time-based prospective memory (TBPM) and event-based prospective memory (EBPM) performance. Other cognitive functions (involving respective memory and executive functions) were evaluated with standardized tests. After controlling for basic demographic characteristics including age, gender and educational level, there was a significant difference between FDRs, FES and HCs with respect to both TBPM (F(2,142) = 10.4, p<0.001) and EBPM (F(2,142) = 10.8, p<0.001). Multiple linear regression analyses revealed that lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the STROOP Word-Color Test (SWCT) contributed to TBPM impairment, while lower educational level and higher scores of the Color Trails Test-2 (CTT-2) contributed to EBPM deficit in FDRs. FDRs share similar but attenuated prospective memory impairments with schizophrenia patients, suggesting that prospective memory deficits may represent an endophenotype of schizophrenia.
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影响因子：
6.7
作者：
Hughes, C;Kumari, V;Sharma, T
通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1080/13803390701779552
发表时间：
2008-01-01
影响因子：
2.2
作者：
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通讯作者：
Zoellig, Jacqueline
影响因子：
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作者：
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通讯作者：
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