Regulation of T lymphopoiesis by Notch1 and Lunatic fringe–mediated competition for intrathymic niches
Regulation of T lymphopoiesis by Notch1 and Lunatic fringe–mediated competition for intrathymic niches
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Notch1 调节 T 淋巴细胞生成和 Lunatic fringe 介导的胸腺内生态位竞争
DOI：
10.1038/ni1345
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发表时间：
2006
影响因子：
30.5
通讯作者：
C. Guidos
中科院分区：
文献类型：
--
作者：
I. Visan;J. Tan;J. Yuan;James A. Harper;U. Koch;C. Guidos
Notch 1激活调节T谱系定型和早期T细胞发育。边缘糖基转移酶改变Notch受体对Delta样Notch配体与Jagged Notch配体的敏感性，但它们在T淋巴细胞生成中的功能尚未确定。在这里，我们表明，发育阶段特异性表达的糖基转移酶lunatic边缘（Lfng）的T细胞祖细胞的胸腺内壁龛，支持Notch 1依赖的阶段的T细胞发育的访问的协调。Lfng-null祖细胞在竞争性测定中产生很少的胸腺细胞，而Lfng过表达将胸腺细胞转化为具有增强的δ样配体结合的“超级竞争者”，并阻断来自正常祖细胞的T淋巴细胞生成。我们认为Lfng和Notch 1控制限制皮质小生境的祖细胞竞争的能力是胸腺大小的稳态调节的重要机制。
Notch1 activation regulates T lineage commitment and early T cell development. Fringe glycosyltransferases alter the sensitivity of Notch receptors to Delta-like versus Jagged Notch ligands, but their functions in T lymphopoiesis have not been defined. Here we show that developmental stage–specific expression of the glycosyltransferase lunatic fringe (Lfng) is required for coordination of the access of T cell progenitors to intrathymic niches that support Notch1-dependent phases of T cell development. Lfng-null progenitors generated few thymocytes in competitive assays, whereas Lfng overexpression converted thymocytes into 'supercompetitors' with enhanced binding of Delta-like ligands and blocked T lymphopoiesis from normal progenitors. We suggest that the ability of Lfng and Notch1 to control progenitor competition for limiting cortical niches is an important mechanism for the homeostatic regulation of thymus size.
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影响因子：
32.4
作者：
Deftos, ML;Huang, E;Bevan, MJ
通讯作者：
Bevan, MJ
影响因子：
56.9
作者：
Phillips, RL;Ernst, RE;Lemischka, IR
通讯作者：
Lemischka, IR
影响因子：
4.4
作者：
Foss, DL;Donskoy, E;Goldschneider, I
通讯作者：
Goldschneider, I
影响因子：
32.4
作者：
Deftos, ML;He, YW;Bevan, MJ
通讯作者：
Bevan, MJ
DOI：
10.1073/pnas.92.22.10302
发表时间：
1995-10-24
影响因子：
11.1
作者：
MORRISON, SJ;HEMMATI, HD;WEISSMAN, IL
通讯作者：
WEISSMAN, IL