Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease.
Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease.
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DOI:
10.3390/jof3010006
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发表时间:
2017-02-10
期刊:
影响因子:
--
通讯作者:
Tirado-Sánchez A
中科院分区:
文献类型:
--
作者:
Bonifaz A;Tirado-Sánchez A
Sporotrichosis is an implantation or inoculation mycosis caused by species of Sporothrix schenckii complex; its main manifestations are limited to skin; however, cutaneous-disseminated, disseminated (visceral) and extracutaneous variants of sporotrichosis can be associated with immunosuppression, including HIV-AIDS, chronic alcoholism or more virulent strains. The most common extracutaneous form of sporotrichosis includes pulmonary, osteoarticular and meningeal. The laboratory diagnosis requires observing yeast forms and isolating the fungus; the two main causative agents are Sporothrix schenckii (ss) and Sporothrix brasiliensis. Antibody levels and species recognition by Polimerase Chain Reaction using biological samples or cultures are also useful. The treatment of choice for most cases is amphotericin B and subsequent itraconazole for maintenance therapy.
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