Comparison of Three Non-Invasive Transcranial Electrical Stimulation Methods for Increasing Cortical Excitability.
Comparison of Three Non-Invasive Transcranial Electrical Stimulation Methods for Increasing Cortical Excitability.
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DOI：
10.3389/fnhum.2016.00668
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发表时间：
2016
影响因子：
2.9
通讯作者：
Onishi H
中科院分区：
文献类型：
--
作者：
Inukai Y;Saito K;Sasaki R;Tsuiki S;Miyaguchi S;Kojima S;Masaki M;Otsuru N;Onishi H
经颅直流电刺激（tDCS）是一种具有代表性的非侵入性脑刺激方法（NIBS）。tDCS不仅在健康个体中增加皮质兴奋性，而且在中风患者中也增加皮质兴奋性，在中风患者中，tDCS有助于运动功能改善。最近，已经引入了另外两种类型的经颅电刺激（tES）方法，它们也可能被证明有利于刺激皮质兴奋性;它们是经颅随机噪声刺激（tRNS）和经颅交流电刺激（tACS）。然而，tDCS与tRNS和tACS在皮质兴奋性改变方面的疗效比较迄今尚未报道。我们使用相同的受试者群体和相同的电流强度，比较了三种不同的tES方法增加皮质兴奋性的有效性。15名健康受试者参加了本研究。三种刺激条件（tDCS、tRNS和tACS）使用了相似的刺激模式（1.0 mA和10 min）。通过单脉冲经颅磁刺激诱发运动诱发电位（MEP）探讨皮层兴奋性。与测量前相比，tDCS、tACS和tRNS的MEP显著增加（p < 0.05）。与假手术测量相比，tRNS和tACS也观察到MEP显著增加（p < 0.05），但tDCS未观察到。此外，在tRNS和tACS之间观察到平均刺激效应的显著相关性（p = 0.019，r = 0.598）。在所有时间点，与Pre或Sham相比，tRNS诱导MEP显著增加。tRNS导致了欧洲议会议员人数的最大幅度增加。这些结果表明，tRNS是最有效的tES方法，应被视为改善卒中患者运动功能的治疗计划的一部分。
Transcranial direct current stimulation (tDCS) is a representative non-invasive brain stimulation method (NIBS). tDCS increases cortical excitability not only in healthy individuals, but also in stroke patients where it contributes to motor function improvement. Recently, two additional types of transcranial electrical stimulation (tES) methods have been introduced that may also prove beneficial for stimulating cortical excitability; these are transcranial random noise stimulation (tRNS) and transcranial alternating current stimulation (tACS). However, comparison of tDCS with tRNS and tACS, in terms of efficacy in cortical excitability alteration, has not been reported thus far. We compared the efficacy of the three different tES methods for increasing cortical excitability using the same subject population and same current intensity. Fifteen healthy subjects participated in this study. Similar stimulation patterns (1.0 mA and 10 min) were used for the three conditions of stimulation (tDCS, tRNS, and tACS). Cortical excitability was explored via single-pulse TMS elicited motor evoked potentials (MEPs). Compared with pre-measurements, MEPs significantly increased with tDCS, tACS, and tRNS (p < 0.05). Compared with sham measurements, significant increases in MEPs were also observed with tRNS and tACS (p < 0.05), but not with tDCS. In addition, a significant correlation of the mean stimulation effect was observed between tRNS and tACS (p = 0.019, r = 0.598). tRNS induced a significant increase in MEP compared with the Pre or Sham at all time points. tRNS resulted in the largest significant increase in MEPs. These findings suggest that tRNS is the most effective tES method and should be considered as part of a treatment plan for improving motor function in stroke patients.
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影响因子：
4.8
作者：
Puri R;Hinder MR;Fujiyama H;Gomez R;Carson RG;Summers JJ
通讯作者：
Summers JJ
影响因子：
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影响因子：
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