Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis.
Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis.
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DOI：
10.1186/1758-5996-4-13
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发表时间：
2012-04-19
影响因子：
4.8
通讯作者：
Katulanda P
中科院分区：
文献类型：
--
作者：
Jayawardena R;Ranasinghe P;Galappatthy P;Malkanthi R;Constantine G;Katulanda P
患有糖尿病和糖尿病前期的人数呈指数级增长。对人类的研究表明，补充锌对糖尿病患者具有有益作用。本研究旨在系统评估文献并荟萃分析补锌对糖尿病的影响。对已发表的报告补充锌对糖尿病影响的研究进行了系统回顾。在以下数据库中进行了文献检索； PubMed、Web of Science 和 SciVerse Scopus。对补充锌对糖尿病患者临床和生化参数影响的研究进行了荟萃分析。本综述纳入的文章总数为25篇，其中包括3篇关于1型糖尿病的研究和22篇关于2型糖尿病的研究。有 12 项研究比较了补锌对 2 型糖尿病患者空腹血糖的影响。补锌组和安慰剂组之间空腹血糖的汇总平均差异为 18.13mg/dl (95%CI:33.85,2.41；p<0.05)。锌治疗组的餐后 2 小时血糖也显示出类似的明显降低（34.87mg/dl [95%CI:75.44; 5.69]）。锌治疗组的 HbA1c 降低了 0.54% (95%CI:0.86;0.21)。有 8 项研究比较了补充锌对 2 型糖尿病患者血脂参数的影响。补锌组和安慰剂组之间总胆固醇的汇总平均差异为 32.37mg/dl (95%CI:57.39,7.35；p<0.05)。锌治疗组中低密度脂蛋白胆固醇也显示出类似的明显降低，随机效应分析的汇总平均差异为 11.19mg/dl (95%CI:21.14,1.25；p<0.05)。研究还表明，补充锌后收缩压和舒张压显着降低。这是关于补充锌对糖尿病患者影响的首次全面系统回顾和荟萃分析，表明补充锌对血糖控制和促进健康的血脂参数具有有益作用。需要进一步的研究来确定造成这些结果的确切生物学机制。
The number of people with diabetes and pre-diabetes are exponentially increasing. Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes. The present study aims to systematically evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes. A systematic review of published studies reporting the effects of Zinc supplementations on diabetes mellitus was undertaken. The literature search was conducted in the following databases; PubMed, Web of Science and SciVerse Scopus. A meta-analysis of studies examining the effects of Zinc supplementation on clinical and biochemical parameters in patients with diabetes was performed. The total number of articles included in the present review is 25, which included 3 studies on type-1 diabetes and 22 studies on type-2 diabetes. There were 12 studies comparing the effects of Zinc supplementation on fasting blood glucose in patients with type-2 diabetes. The pooled mean difference in fasting blood glucose between Zinc supplemented and placebo groups was 18.13mg/dl (95%CI:33.85,2.41; p<0.05). 2-h post-prandial blood sugar also shows a similar distinct reduction in (34.87mg/dl [95%CI:75.44; 5.69]) the Zinc treated group. The reduction in HbA1c was 0.54% (95%CI:0.86;0.21) in the Zinc treated group. There were 8 studies comparing the effects of Zinc supplementation on lipid parameters in patients with type-2 diabetes. The pooled mean difference for total cholesterol between Zinc supplemented and placebo groups was 32.37mg/dl (95%CI:57.39,7.35; p<0.05). Low-density lipoprotein cholesterol also showed a similar distinct reduction in the Zinc treated group, the pooled mean difference from random effects analysis was 11.19mg/dl (95%CI:21.14,1.25; p<0.05). Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation. This first comprehensive systematic review and meta-analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation has beneficial effects on glycaemic control and promotes healthy lipid parameters. Further studies are required to identify the exact biological mechanisms responsible for these results.
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影响因子：
5.1
作者：
Farvid, Maryam Sadat;Homayouni, Fatemeh;Adelmanesh, Farhad
通讯作者：
Adelmanesh, Farhad
影响因子：
16.2
作者：
Farvid, MS;Jalali, M;Hosseini, M
通讯作者：
Hosseini, M
影响因子：
120.7
作者：
CHANDRA, RK
通讯作者：
CHANDRA, RK
影响因子：
6.8
作者：
Dodson, G;Steiner, D
通讯作者：
Steiner, D
影响因子：
4.2
作者：
Black, RE
通讯作者：
Black, RE