Silver telluride nanoparticles as biocompatible and enhanced contrast agents for X-ray imaging: an in vivo breast cancer screening study.
Silver telluride nanoparticles as biocompatible and enhanced contrast agents for X-ray imaging: an in vivo breast cancer screening study.
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DOI：
10.1039/d0nr05489e
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发表时间：
2021-01-08
期刊：
影响因子：
6.7
通讯作者：
Cormode DP
中科院分区：
文献类型：
--
作者：
Nieves LM ;Hsu JC ;Lau KC ;Maidment ADA ;Cormode DP
硫化银纳米粒子（Ag2S NPs）由于其光热消融增强、近红外荧光性质、低毒性水平和多成像能力而在生物医学领域获得了相当大的兴趣。银碲化物纳米颗粒（Ag2Te NPs）具有与Ag2S NPs类似的性质，由于极低的溶度积，也应该是稳定的，并且应该产生更大的X射线对比度，因为碲在诊断X射线能量下比硫明显更衰减。尽管有这些有吸引力的特性，Ag2Te NPs仅在体内研究过一次，并且剂量较低（每公斤2毫克Ag）。在此，第一次在体内研究了Ag2Te NPs的性质及其在生物医学领域中的应用，该研究需要所有生物医学应用中最高的纳米颗粒剂量，即X射线成像。研究表明，Ag2 TeNP具有稳定性、生物相容性（在研究的细胞系或体内未观察到急性毒性），并且在研究的两种X射线成像技术（计算机断层扫描（CT）和双能X射线成像）中产生了比对照更高的对比度。能量乳房X射线摄影术（DEM）。总之，这是第一项研究，其中Ag2Te纳米颗粒在体内探索高剂量。我们的研究结果表明，Ag2Te纳米颗粒提供了强大的X射线对比度，同时表现出良好的生物相容性。这些结果突出了Ag2Te NPs在生物医学领域和作为乳腺癌筛查的X射线造影剂的潜在用途。
Silver sulfide nanoparticles (Ag2S NPs) have gained considerable interest in the biomedical field due to their photothermal ablation enhancement, near-infrared fluorescence properties, low toxicity levels, and multi-imaging capabilities. Silver telluride nanoparticles (Ag2Te NPs) have similar properties to Ag2S NPs, should also be stable due to an extremely low solubility product and should generate greater X-ray contrast since tellurium is significantly more attenuating than sulfur at diagnostic X-ray energies. Despite these attractive properties, Ag2Te NPs have only been studied in vivo once and at a low dose (2 mg Ag per kg). Herein, for the first time, Ag2Te NPs’ properties and their application in the biomedical field were studied in vivo in the setting requiring the highest nanoparticle doses of all biomedical applications, i.e. X-ray imaging. Ag2Te NPs were shown to be stable, biocompatible (no acute toxicity observed in the cell lines studied or in vivo), and generated higher contrast, compared to controls, in the two X-ray imaging techniques studied: computed tomography (CT) and dual-energy mammography (DEM). In summary, this is the first study where Ag2Te NPs were explored in vivo at a high dose. Our findings suggest that Ag2Te NPs provide strong X-ray contrast while exhibiting excellent biocompatibility. These results highlight the potential use of Ag2Te NPs in the biomedical field and as X-ray contrast agents for breast cancer screening.
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影响因子：
6.7
作者：
Hsu JC ;Naha PC ;Lau KC ;Chhour P ;Hastings R ;Moon BF ;Stein JM ;Witschey WRT ;McDonald ES ;Maidment ADA ;Cormode DP
通讯作者：
Cormode DP
DOI：
10.1021/acs.chemmater.9b03931
发表时间：
2020-01-14
期刊：
Chemistry of materials : a publication of the American Chemical Society
影响因子：
--
作者：
Kim J;Silva AB;Hsu JC;Maidment PSN;Shapira N;Noël PB;Cormode DP
通讯作者：
Cormode DP
影响因子：
3.5
作者：
Karunamuni, R.;Maidment, A. D. A.
通讯作者：
Maidment, A. D. A.
影响因子：
19.7
作者：
Jochelson, Maxine S.;Dershaw, D. David;Morris, Elizabeth A.
通讯作者：
Morris, Elizabeth A.
DOI：
10.1007/978-1-60327-198-1_6
发表时间：
2011-01-01
期刊：
CHARACTERIZATION OF NANOPARTICLES INTENDED FOR DRUG DELIVERY
影响因子：
--
作者：
Clogston, Jeffrey D.;Patri, Anil K.
通讯作者：
Patri, Anil K.