Radioprotective garment-inspired biodegradable polymetal nanoparticles for enhanced CT contrast production.
Radioprotective garment-inspired biodegradable polymetal nanoparticles for enhanced CT contrast production.
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DOI：
10.1021/acs.chemmater.9b03931
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发表时间：
2020-01-14
期刊：
影响因子：
--
通讯作者：
Cormode DP
中科院分区：
文献类型：
--
作者：
Kim J;Silva AB;Hsu JC;Maidment PSN;Shapira N;Noël PB;Cormode DP
由重金属元素制成的基于纳米颗粒的X射线计算机断层扫描（CT）造影剂的许多配方正在研究其提供改进的CT成像的能力。到目前为止，大多数实验性的基于纳米颗粒的CT造影剂已经用单个元素的原子开发。然而，受辐射防护服装中使用的多种元素形成的复合材料的启发，我们假设由K边缘能量在高光子通量区域中间隔开的几种元素制成的造影剂可以在X射线源光谱中使用的能量上实现高宽带X射线衰减。本文中，我们合成了含有金、钽和铈的亚5 nm核无机纳米颗粒，并将它们封装在聚合物纳米颗粒中以形成多金属纳米颗粒（PMNP）。我们发现，具有多个有效载荷元件的PMNP比由单一造影剂产生材料制成的造影剂产生更高和更稳定的CT造影剂，证明了结合多个合适的元件作为CT造影剂有效载荷的潜在益处。
Numerous formulations of nanoparticle-based X-ray computed tomography (CT) contrast agents made of heavy metal elements are under investigation for their ability to provide improved CT imaging. Thus far, most experimental nanoparticle-based CT contrast agents have been developed with atoms of a single element. However, inspired by the composites formed from multiple elements used in radioprotective garments, we hypothesized that contrast agents made of several elements whose K-edge energies are spaced out in the high photon flux region could achieve high, broadband X-ray attenuation across the energies used in X-ray source spectra. Herein, we synthesized sub-5 nm core inorganic nanoparticles containing gold, tantalum, and cerium, and encapsulated them in polymeric nanoparticles to form polymetal nanoparticles (PMNP). We found that PMNP with multiple payload elements generate higher and more stable CT contrast than contrast agents made from a single contrast generating material, demonstrating the potential benefits of incorporating multiple suitable elements as CT contrast payloads.
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影响因子：
6.7
作者：
Hsu JC ;Naha PC ;Lau KC ;Chhour P ;Hastings R ;Moon BF ;Stein JM ;Witschey WRT ;McDonald ES ;Maidment ADA ;Cormode DP
通讯作者：
Cormode DP
影响因子：
9.5
作者：
Hernandez-Rivera, Mayra;Kumar, Ish;Wilson, Lon J.
通讯作者：
Wilson, Lon J.
影响因子：
17.1
作者：
Bonitatibus, Peter J., Jr.;Torres, Andrew S.;Marino, Michael E.
通讯作者：
Marino, Michael E.
影响因子：
--
作者：
Cormode, David P.;Naha, Pratap C.;Fayad, Zahi A.
通讯作者：
Fayad, Zahi A.
影响因子：
17.1
作者：
Chhour, Peter;Gallo, Nicolas;Cheheltani, Rabee;Williams, Dewight;Al-Zaki, Ajlan;Paik, Taejong;Nichol, Jessica L.;Tian, Zhicheng;Naha, Pratap C.;Witschey, Walter R.;Allcock, Harry R.;Murray, Christopher B.;Tsourkas, Andrew;Cormode, David P.
通讯作者：
Cormode, David P.