Caregiver-reported adherence to antiretroviral therapy among HIV infected children in Mekelle, Ethiopia.
Caregiver-reported adherence to antiretroviral therapy among HIV infected children in Mekelle, Ethiopia.
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DOI：
10.1186/1471-2431-14-114
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发表时间：
2014-04-27
期刊：
影响因子：
2.4
通讯作者：
Berhane L
中科院分区：
文献类型：
--
作者：
Eticha T;Berhane L
儿童抗逆转录病毒治疗（ART）的依从性是复杂的，可能是由于许多因素，如儿童的特点，照顾者和家庭的特点，方案的特点，等等，因此，重要的是要确定与艾滋病毒感染的儿童依从性的相关因素，以减少发展的风险，通过干预治疗失败或耐药性。这项调查的目的是了解埃塞俄比亚提格雷州Mekelle儿童坚持抗逆转录病毒疗法的比例及其相关因素。2013年2月至3月期间，在Mekelle的两家医院：Ayder转诊医院和Mekelle医院进行了一项横断面调查。一个结构化的问卷管理照顾者，以评估病人的依从性。在总共193名患者中，83.4%的护理人员在访谈前7天内坚持接受抗逆转录病毒治疗。多因素Logistic回归分析发现，父母未婚（AOR = 15.17，95%CI：3.36-68.43）和已婚（AOR = 3.54，95%CI：1.23-10.13）的儿童比父母离异/分居的儿童更容易坚持ART治疗。同样，照顾者年龄组为25-34岁（AOR = 22.27，95%CI：4.34-114.29）和35-44岁（AOR = 7.14，95%CI：1.65-30.95）的儿童比同龄人更容易坚持。照顾者报告的丢失药物的主要原因包括：儿童抑郁症（24.4%），药物副作用（16.3%），太多的药丸（15.5%）和吞咽困难（13.3%）。儿童中坚持抗逆转录病毒治疗的流行率很高，与其他类似机构相当。尽管如此，鼓励照顾者发挥基本作用对于改善漏服一剂或更多剂量者的依从性，从而改善艾滋病毒感染儿童的治疗结果至关重要。
Adherence to antiretroviral therapy (ART) in children is complicated may be because of many factors such as child characteristics, caregiver and family characteristics, regimen characteristics, etc. Therefore, it is important to identify factors associated with adherence in HIV infected children in order to reduce the risk of developing treatment failure or drug resistance through interventions. This survey was planned to find out the rate of adherence to ART and its associated factors among the children in Mekelle, Tigray region, Ethiopia. A cross-sectional survey was conducted in two hospitals in Mekelle: Ayder Referral Hospital and Mekelle Hospital, during the months of February to March 2013. A structured questionnaire was administered to caregivers to assess patient’s adherence. Out of a total of 193 patients, 83.4% as reported by caregivers were adherent to ART in the past seven days before the interview. On multivariate logistic regression model, it was found that the children whose caregivers were unmarried (AOR = 15.17, 95% CI: 3.36-68.43) and married (AOR = 3.54, 95% CI: 1.23-10.13) were more likely to adhere to their ART treatment than those whose caregivers were divorced/separated. Similarly, children whose caregivers’ age groups of 25–34 (AOR = 22.27, 95% CI: 4.34-114.29) and 35–44 (AOR = 7.14, 95% CI: 1.65-30.95) were more likely to adhere than their counterparts. The major reasons reported by caregivers for missing medicines include: child being depressed (24.4%), drug side effects (16.3%), too many pills (15.5%) and difficulty in swallowing pills (13.3%). The prevalence of adherence to ART among children was found to be high and comparable to that of other similar setups. Nevertheless, encouraging the fundamental role of caregivers is so significant to improve adherence among those who missed a dose or more and consequently treatment outcomes of children with HIV.
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影响因子：
4.5
作者：
Hansana V;Sanchaisuriya P;Durham J;Sychareun V;Chaleunvong K;Boonyaleepun S;Schelp FP
通讯作者：
Schelp FP
影响因子：
2.4
作者：
Biressaw S;Abegaz WE;Abebe M;Taye WA;Belay M
通讯作者：
Belay M
DOI：
10.2989/16085900609490374
发表时间：
2006-09-01
期刊：
African journal of AIDS research : AJAR
影响因子：
--
作者：
Mukhtar-Yola, Mariya;Adeleke, Solomon;Ladan, Zubaida Farouk
通讯作者：
Ladan, Zubaida Farouk
影响因子：
2.4
作者：
Biadgilign, Sibhatu;Deribew, Amare;Deribe, Kebede
通讯作者：
Deribe, Kebede
影响因子：
3.6
作者：
Vreeman, Rachel C.;Wiehe, Sarah E.;Nvandiko, Winstone M.
通讯作者：
Nvandiko, Winstone M.