Covalent Bonding of an Electroconductive Hydrogel to Gold-Coated Titanium Surfaces via Thiol-ene Click Chemistry
Covalent Bonding of an Electroconductive Hydrogel to Gold-Coated Titanium Surfaces via Thiol-ene Click Chemistry
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通过硫醇-烯点击化学将导电水凝胶与镀金钛表面共价键合
DOI：
10.1002/mame.201600296
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发表时间：
2016-09
影响因子：
3.9
通讯作者：
Ning Chengyun
中科院分区：
文献类型：
--
作者：
Tan Guoxin;Liu Yan;Zhou Lei;Ouyang Kongyou;Wang Zhengao;Yu Peng;Ning Chengyun
在本研究中，通过紫外光引发的自由基硫醇-烯点击反应，研究了具有电性能和水凝胶特性的双交联水凝胶网络与钛表面的共价键合。通过钛植入物支撑的明胶甲基丙烯酸酯水凝胶内吡咯的电聚合形成可固化水凝胶层。层的表面形态的表征揭示了独特的粗糙大孔结构。钛表面上的水凝胶涂层由于化学官能化的作用而具有高电化学活性和高机械稳定性的期望特性。在水凝胶基质上培养的骨髓间充质干细胞表现出高细胞活力。这项研究是第一次证明了一种可降解水凝胶作为钛植入物表面涂层用于细胞生长的潜力，并为开发新的可植入生物电子器件提供了基础。
In the present study, the covalent bonding of electroconductive cross-linked hydrogel networks with both electro-properties and hydrogel characteristics to titanium surfaces via a UV-initiated radical thiol-ene click reaction is investigated. The electroconductive hydrogel layers are formed by the electropolymerization of pyrrole within the titanium implant-supported gelatin methacrylate hydrogel. Characterization of the surface morphology of the layers reveals a unique rough macroporous structure. The hydrogel coating layer on the titanium surfaces possesses the desired characteristics of high electrochemical activity and high mechanical stability due to the effects of the chemical functionalization. Bone mesenchymal stem cells cultured on the hydrogel substrates exhibit high cell viability. This study is the first to demonstrate the potential of an electroconductive hydrogel as a surface coating on titanium implants for cell growth and provides a foundation for the development of new implantable bioelectronic devices.
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影响因子：
14
作者：
Nichol, Jason W.;Koshy, Sandeep T.;Bae, Hojae;Hwang, Chang M.;Yamanlar, Seda;Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali
影响因子：
14
作者：
Yue K;Trujillo-de Santiago G;Alvarez MM;Tamayol A;Annabi N;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
12.6
作者：
S. N. Topkaya
通讯作者：
S. N. Topkaya
影响因子：
4.4
作者：
Ling-Yan Liu;Jiejun Yang;Yunpeng Jiang;Yaoqing Huang;Q. Meng
通讯作者：
Ling-Yan Liu;Jiejun Yang;Yunpeng Jiang;Yaoqing Huang;Q. Meng
影响因子：
12.6
作者：
Yanyan Yu;Zuanguang Chen;Sijing He;Beibei Zhang;Xinchun Li;Meicun Yao
通讯作者：
Yanyan Yu;Zuanguang Chen;Sijing He;Beibei Zhang;Xinchun Li;Meicun Yao