Exhaled breath analysis: a review of 'breath-taking' methods for off-line analysis.
Exhaled breath analysis: a review of 'breath-taking' methods for off-line analysis.
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DOI：
10.1007/s11306-017-1241-8
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Fowler SJ
中科院分区：
文献类型：
--
作者：
Lawal O;Ahmed WM;Nijsen TME;Goodacre R;Fowler SJ
呼出气采样和分析的潜力长期以来吸引了医学诊断和疾病监测领域的兴趣。这种兴趣归因于其非侵入性，可获得无限的样品供应（即，呼吸），以及促进快速诊断患者的潜力。然而，从实验室环境到常规临床实践的进展缓慢。不同的呼吸采样方法，以及随之而来的比较和合并数据的困难，被认为是一个主要因素。为了在临床和临床前医学中实现呼吸分析的潜力，呼吸采样和分析的一些方法的标准化将是有益的。本综述的目的是通过深入的文献计量学搜索来研究呼吸采样方法的异质性，以确定该领域的当前技术水平。此外，审查将讨论和评论各种呼吸采样方法离线呼吸分析。使用可提供同行评审文章的MEDLINE平台，在MEDLINE、BIOSIS、EMBASE、INSPEC、COMPENDEX、PQSCITECH和SCISETECH数据库中进行文献检索。搜索的关键词包括呼吸、采样、收集、预浓缩、挥发性。然后对最初纳入的文章进行正向和反向检索。随后审查了所有纳入文献的呼吸采集方法。不同研究小组的采样方法不同，例如针对呼吸的部分。呼气末呼吸的定义因研究而异。呼吸分析是一个跨学科的研究领域，使用临床，分析化学，数据处理和代谢组学专业知识。目前，呼吸研究界正在推动呼吸采样标准化，以期协调分析，从而提高稳健性和实验室间的比较。本文的在线版本（doi：10.1007/s11306-017-1241-8）包含补充材料，可供授权用户使用。
The potential of exhaled breath sampling and analysis has long attracted interest in the areas of medical diagnosis and disease monitoring. This interest is attributed to its non-invasive nature, access to an unlimited sample supply (i.e., breath), and the potential to facilitate a rapid at patient diagnosis. However, progress from laboratory setting to routine clinical practice has been slow. Different methodologies of breath sampling, and the consequent difficulty in comparing and combining data, are considered to be a major contributor to this. To fulfil the potential of breath analysis within clinical and pre-clinical medicine, standardisation of some approaches to breath sampling and analysis will be beneficial. The aim of this review is to investigate the heterogeneity of breath sampling methods by performing an in depth bibliometric search to identify the current state of art in the area. In addition, the review will discuss and critique various breath sampling methods for off-line breath analysis. Literature search was carried out in databases MEDLINE, BIOSIS, EMBASE, INSPEC, COMPENDEX, PQSCITECH, and SCISEARCH using the STN platform which delivers peer-reviewed articles. Keywords searched for include breath, sampling, collection, pre-concentration, volatile. Forward and reverse search was then performed on initially included articles. The breath collection methodologies of all included articles was subsequently reviewed. Sampling methods differs between research groups, for example regarding the portion of breath being targeted. Definition of late expiratory breath varies between studies. Breath analysis is an interdisciplinary field of study using clinical, analytical chemistry, data processing, and metabolomics expertise. A move towards standardisation in breath sampling is currently being promoted within the breath research community with a view to harmonising analysis and thereby increasing robustness and inter-laboratory comparisons. The online version of this article (doi:10.1007/s11306-017-1241-8) contains supplementary material, which is available to authorized users.
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影响因子：
3.1
作者：
Bikov A;Hernadi M;Korosi BZ;Kunos L;Zsamboki G;Sutto Z;Tarnoki AD;Tarnoki DL;Losonczy G;Horvath I
通讯作者：
Horvath I
影响因子：
6.7
作者：
Bos LD;Sterk PJ;Schultz MJ
通讯作者：
Schultz MJ
影响因子：
6.4
作者：
Amal, Haitham;Leja, Marcis;Haick, Hossam
通讯作者：
Haick, Hossam
基于表面增强拉曼散射传感器的呼吸分析可区分早期和晚期胃癌患者与健康人。
影响因子：
17.1
作者：
Chen, Yunsheng;Zhang, Yixia;Cui, Daxiang
通讯作者：
Cui, Daxiang
影响因子：
4.6
作者：
Capuano R;Santonico M;Pennazza G;Ghezzi S;Martinelli E;Roscioni C;Lucantoni G;Galluccio G;Paolesse R;Di Natale C;D'Amico A
通讯作者：
D'Amico A