The two-body problem: Proprioception and motor control across the metamorphic divide.

The two-body problem: Proprioception and motor control across the metamorphic divide.
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DOI:
10.1016/j.conb.2022.102546
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发表时间:
2022-06
影响因子:
5.7
通讯作者:
--
中科院分区:
医学2区
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--
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就像火箭被推进太空一样,进化使苍蝇通过多个阶段进入成年期。苍蝇发育和部署两个不同的身体,通过变态的转变过程联系在一起。苍蝇幼虫是一种柔软的液压管,可以爬行寻找食物和躲避捕食者。成年苍蝇的外骨骼僵硬,四肢有关节,可以进行远距离导航和丰富的社交活动。由于幼虫和成虫在结构上非常不同,它们需要不同的感知和移动身体的策略。因此,变质划分为神经回路的比较分析提供了机会。在这里,我们综述了在幼虫和成年果蝇中理解本体感觉和运动控制的神经机制的最新进展。我们强调的共同点指向感觉运动控制的一般原则,以及可能反映生物力学施加的独特约束的差异。最后,我们讨论了对苍蝇和其他动物物种的神经回路结构进行比较分析的新机会。
Like a rocket being propelled into space, evolution has engineered flies to launch into adulthood via multiple stages. Flies develop and deploy two distinct bodies, linked by the transformative process of metamorphosis. The fly larva is a soft hydraulic tube that can crawl to find food and avoid predators. The adult fly has a stiff exoskeleton with articulated limbs that enable long-distance navigation and rich social interactions. Because the larval and adult forms are so distinct in structure, they require distinct strategies for sensing and moving the body. The metamorphic divide thus presents an opportunity for comparative analysis of neural circuits. Here, we review recent progress toward understanding the neural mechanisms of proprioception and motor control in larval and adult Drosophila. We highlight commonalities that point toward general principles of sensorimotor control and differences that may reflect unique constraints imposed by biomechanics. Finally, we discuss emerging opportunities for comparative analysis of neural circuit architecture in the fly and other animal species.
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