Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb.
Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb.
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DOI：
10.1016/j.envres.2015.03.008
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发表时间：
2015-07
影响因子：
8.3
通讯作者：
Zheng, Wei
中科院分区：
文献类型：
--
作者：
Zhang, Long-Lian;Lu, Ling;Pan, Ya-Juan;Ding, Chun-Guang;Xu, Da-Yong;Huang, Chuan-Feng;Pan, Xing-Fu;Zheng, Wei
金属的基线血液浓度是监测环境和职业环境中金属暴露的重要参考。本研究的目的是测定中国北京西南郊区居民（12-60岁）血液中锰（Mn）、铜（Cu）、锌（Zn）、铅（Pb）和镉（Cd）的含量，并将结果与各个发达国家的报告值进行比较。 2009 年 3 月至 2010 年 2 月期间，从 648 名受试者采集了血液样本。通过 ICP-MS 测定了全血中的金属浓度。血液中锰、铜、锌、铅和镉的几何平均值分别为11.4、802.4、4665、42.6和0.68μg/L。男性受试者的血铅含量高于女性，而女性受试者的血锰和铜含量高于男性。血液中镉和锌的含量没有性别差异。吸烟者的血液铜、锌和镉含量高于不吸烟者。所研究的所有金属的血液浓度均存在与年龄相关的显着差异； 17-30岁年龄组的受试者血液中锰、铅、铜和锌的含量较高，而46-60岁年龄组的受试者的镉含量高于其他年龄组。与其他发达国家的居民相比，该人群的血液铜和锌水平明显较低。根据目前的研究，血锰的正常参考范围估计为5.80-25.2μ/L；血铜，541–1475 μ/L；血锌，2349–9492 μ/L；血Pb<100μ/L；居住在北京郊区的一般人群血镉含量<5.30 μ/L。
Baseline blood concentrations of metals are important references for monitoring metal exposure in environmental and occupational settings. The purpose of this study was to determine the blood levels of manganese (Mn), copper (Cu), zinc (Zn), lead (Pb), and cadmium (Cd) among the residents (aged 12–60 years old) living in the suburb southwest of Beijing in China and to compare the outcomes with reported values in various developed countries. Blood samples were collected from 648 subjects from March 2009 to February 2010. Metal concentrations in the whole blood were determined by ICP-MS. The geometric means of blood levels of Mn, Cu, Zn, Pb and Cd were 11.4, 802.4, 4665, 42.6, and 0.68 μg/L, respectively. Male subjects had higher blood Pb than the females, while the females had higher blood Mn and Cu than the males. There was no gender difference for blood Cd and Zn. Smokers had higher blood Cu, Zn, and Cd than nonsmokers. There were significant age-related differences in blood levels of all metals studied; subjects in the 17–30 age group had higher blood levels of Mn, Pb, Cu, and Zn, while those in the 46–60 age group had higher Cd than the other age groups. A remarkably lower blood level of Cu and Zn in this population as compared with residents of other developed countries was noticed. Based on the current study, the normal reference ranges for the blood Mn were estimated to be 5.80–25.2 μ/L; for blood Cu, 541–1475 μ/L; for blood Zn, 2349–9492 μ/L; for blood Pb, <100 μ/L; and for blood Cd, <5.30 μ/L in the general population living in Beijing suburbs.
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影响因子：
4.3
作者：
Bjermo, Helena;Sand, Salomon;Darnerud, Per Ola
通讯作者：
Darnerud, Per Ola
DOI：
10.1078/1438-4639-00155
发表时间：
2002-05-01
影响因子：
6
作者：
Becker, K;Kaus, S;Seifert, B
通讯作者：
Seifert, B
DOI：
10.1016/j.jtemb.2006.08.001
发表时间：
2006-01-01
影响因子：
3.5
作者：
Heitland, Peter;Koester, Helmut D.
通讯作者：
Koester, Helmut D.
DOI：
10.1016/j.jtemb.2010.12.004
发表时间：
2011-01-01
影响因子：
3.5
作者：
Bocca, Beatrice;Madeddu, Roberto;Forte, Giovanni
通讯作者：
Forte, Giovanni
影响因子：
3.5
作者：
Gu, Huiying;Robison, Gregory;Hong, Lan;Barrea, Raul;Wei, Xing;Farlow, Martin R.;Pushkar, Yulia N.;Du, Yansheng;Zheng, Wei
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Zheng, Wei