Pilot study of fetal brain development and morphometry in prenatal opioid exposure and smoking on fetal MRI.
Pilot study of fetal brain development and morphometry in prenatal opioid exposure and smoking on fetal MRI.
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DOI：
10.1016/j.neurad.2020.12.004
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Sadhasivam S
中科院分区：
文献类型：
--
作者：
Radhakrishnan R;Brown BP;Haas DM;Zang Y;Sparks C;Sadhasivam S
本研究的目的是评估与未暴露于阿片类药物的胎儿相比，在胎儿MRI上暴露于阿片类药物的胎儿在脑成熟、结构和形态测定方面的任何差异。我们对使用阿片类药物的孕妇和产前未使用阿片类药物的健康孕妇进行了前瞻性研究。我们评估了孕中期和孕晚期胎儿MRI的脑成熟度、结构和形态测量学，并评估了组间差异。入组了28名孕妇，12名暴露于阿片类药物（平均胎龄33.67，范围28- 39周），其中9名还吸烟，16名未暴露于阿片类药物（平均胎龄32.53，范围27- 38周）。与未暴露阿片类药物的胎仔相比，暴露阿片类药物的胎仔小脑蚓部的前后径存在显著差异（p=0.004）。与非阿片类暴露胎儿相比，阿片类暴露胎儿的脑双顶径、额枕径、小脑横径和脑桥前后径无显著差异。暴露于阿片类药物的胎儿的大脑成熟没有异常，也没有重大的大脑结构异常。较小的胎儿前后小脑蚓部尺寸与宫内阿片类药物暴露相关。在暴露于阿片类药物的胎儿中，脑成熟或主要结构异常均无异常。
The purpose of this study was to assess for any differences in brain maturation, structure and morphometry in the fetus exposed to opioids in utero, compared to non-opioid exposed fetuses on fetal MRI. We performed a prospective study in pregnant women using opioids and healthy pregnant women without prenatal opioid use. We evaluated brain maturation, structure, and morphometry on second trimester and third trimester fetal MRI and assessed group differences. 28 pregnant women were enrolled, 12 with opioid exposure (average gestational age 33.67, range 28–39w), 9 of whom also smoked, and 16 without opioid exposure (average gestational age 32.53, range 27–38w). There was a significant difference in the anteroposterior diameter of the fetal cerebellar vermis in the opioid exposed fetuses compared to non-opioid exposed fetuses (p=0.004). There was no significant difference in brain biparietal diameter, fronto-occipital diameter, transverse cerebellar diameter and anteroposterior dimension of the pons in opioid exposed fetuses compared to non-opioid exposed fetuses. There were no abnormalities in brain maturation and no major brain structural abnormalities in the opioid exposed fetuses. Smaller fetal anteroposterior cerebellar vermian dimension was associated with in utero opioid exposure. There were no abnormalities in brain maturation or major structural abnormalities in fetuses exposed to opioids.
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