Maternal smoking during pregnancy and fetal organ growth: a magnetic resonance imaging study.
Maternal smoking during pregnancy and fetal organ growth: a magnetic resonance imaging study.
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DOI：
10.1371/journal.pone.0067223
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gowland PA
中科院分区：
文献类型：
--
作者：
Anblagan D;Jones NW;Costigan C;Parker AJ;Allcock K;Aleong R;Coyne LH;Deshpande R;Raine-Fenning N;Bugg G;Roberts N;Pausova Z;Paus T;Gowland PA
研究母亲在怀孕期间吸烟是否与胎儿肺、肾、肝、脑和胎盘的生长变化有关。一项病例对照研究，操作员进行图像分析时设盲。研究在研究专用磁共振成像（MRI）扫描仪（1.5 T）上进行，参与者从英国一家大型教学医院招募。共招募了26名孕妇（13名当前吸烟者，13名非吸烟者）; 18名妇女（10名当前吸烟者，8名非吸烟者）在怀孕后期返回进行第二次扫描。每个胎儿在孕22-27周和33-38周（GA）进行MRI扫描。使用MRI获得的图像来测量胎儿脑、肾、肺、肝的体积和总体胎儿尺寸，以及胎盘体积。暴露的胎仔显示脑体积、肾脏体积和总胎仔体积较低，对于脑和肾脏体积，访视2的影响大于访视1，对于总胎仔体积，访视1的影响大于访视2。暴露的胎仔也表现出较低的肺体积和胎盘体积，这一影响在两次访视时相似。在暴露和未暴露胎仔的肝脏体积方面未发现差异。磁共振成像已被用于显示母亲吸烟与胎儿大脑，肺和肾脏的生长减少有关;即使在母亲教育，孕龄和胎儿性别校正体积时，这种影响仍然存在。正如预期的那样，接触母亲吸烟的胎儿体型较小。同样，吸烟孕妇的胎盘体积也小于不吸烟孕妇。
To study whether maternal cigarette smoking during pregnancy is associated with alterations in the growth of fetal lungs, kidneys, liver, brain, and placenta. A case-control study, with operators performing the image analysis blinded. Study performed on a research-dedicated magnetic resonance imaging (MRI) scanner (1.5 T) with participants recruited from a large teaching hospital in the United Kingdom. A total of 26 pregnant women (13 current smokers, 13 non smokers) were recruited; 18 women (10 current smokers, 8 nonsmokers) returned for the second scan later in their pregnancy. Each fetus was scanned with MRI at 22–27 weeks and 33–38 weeks gestational age (GA). Images obtained with MRI were used to measure volumes of the fetal brain, kidneys, lungs, liver and overall fetal size, as well as placental volumes. Exposed fetuses showed lower brain volumes, kidney volumes, and total fetal volumes, with this effect being greater at visit 2 than at visit 1 for brain and kidney volumes, and greater at visit 1 than at visit 2 for total fetal volume. Exposed fetuses also demonstrated lower lung volume and placental volume, and this effect was similar at both visits. No difference was found between the exposed and nonexposed fetuses with regards to liver volume. Magnetic resonance imaging has been used to show that maternal smoking is associated with reduced growth of fetal brain, lung and kidney; this effect persists even when the volumes are corrected for maternal education, gestational age, and fetal sex. As expected, the fetuses exposed to maternal smoking are smaller in size. Similarly, placental volumes are smaller in smoking versus nonsmoking pregnant women.
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影响因子：
120.7
作者：
Mook-Kanamori, Dennis O.;Steegers, Eric A. P.;Jaddoe, Vincent W. V.
通讯作者：
Jaddoe, Vincent W. V.
DOI：
10.1016/s0002-9378(96)70159-x
发表时间：
1996-08-01
影响因子：
9.8
作者：
Garden, AS;Roberts, N
通讯作者：
Roberts, N
影响因子：
2.8
作者：
Nelson, E;Goubet-Wiemers, C;Jodscheit, K
通讯作者：
Jodscheit, K
影响因子：
2.5
作者：
Gong, QY;Roberts, N;Whithouse, GH
通讯作者：
Whithouse, GH
影响因子：
12.7
作者：
HAGLUND, B;CNATTINGIUS, S
通讯作者：
CNATTINGIUS, S