Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding.
Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding.
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短期胆固醇喂养后，兔主动脉动脉粥样硬化易感部位的血管细胞粘附分子-1和内膜巨噬细胞局部增加。
DOI：
10.1161/01.atv.19.2.393
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Barber,KM
中科院分区：
文献类型：
--
作者：
Truskey,GA;Herrmann,RA;Kait,J;Barber,KM
-我们测试了这样的假设，即兔主动脉病变易发部位内皮细胞上血管细胞黏附分子-1(VCAM-1)的表达与血浆胆固醇暴露相关，巨噬细胞聚集与表达VCAM-1的内皮细胞相关。喂饲0.25%胆固醇2周后，VCAM-1在腹主支远侧部的表达选择性增加。在弓支、腹主动脉支、肠系膜上动脉支和肾动脉支中，VCAM-1的表达与实验期间的血浆胆固醇积分呈正相关。喂饲胆固醇2周后，肋间动脉远端、外侧及腹主支周围巨噬细胞较非分支区明显增多。腹主动脉弓、肋间及腹主支周围巨噬细胞密度与血浆胆固醇积分呈正相关。在病变易发区域，VCAM-1和巨噬细胞水平相关。在正常胆固醇血症兔，23±4%的巨噬细胞与VCAM-1阳性的内皮细胞直接相关。饲喂0.25%胆固醇2周后，这种关联性增加到37±4%(P<；0.015)。主要腹部分支的外侧和远侧区域周围的关联性最高。这些结果表明：(1)VCAM-1的表达和内膜巨噬细胞密度受血浆胆固醇和动脉血流动力学等区域性因素的影响；(2)VCAM-1在巨噬细胞的定位中起重要作用。
—We tested the hypotheses that vascular cell adhesion molecule-1 (VCAM-1) expression on endothelium at lesion-prone sites in the rabbit aorta correlates with exposure to plasma cholesterol and that macrophage accumulation is associated with endothelial cells expressing VCAM-1. After rabbits were fed 0.25% cholesterol for 2 weeks, VCAM-1 expression was selectively increased at the distal and lateral portions of the major abdominal branches. In the arch and the celiac, superior mesenteric, and renal artery branches, VCAM-1 expression was positively correlated with the plasma cholesterol integrated over the duration of the experiments. After 2 weeks of cholesterol feeding, more macrophages were present around distal and lateral portions of the intercostal arteries and major abdominal branches relative to nonbranch regions. In the arch and around the intercostals and major abdominal branches, macrophage densities were positively correlated with the integrated plasma cholesterol. VCAM-1 and macrophage levels were correlated in lesion-prone regions. In normocholesterolemic rabbits, 23±4% (mean±SEM) of the macrophages were directly associated with VCAM-1–positive endothelium. After 2 weeks of 0.25% cholesterol feeding, the association increased to 37±4% (P<0.015). Associations were highest around the lateral and distal regions of the major abdominal branches. These results suggest that (1) VCAM-1 expression and intimal macrophage densities are influenced by plasma cholesterol and regional factors such as arterial fluid dynamics and (2) VCAM-1 plays a significant role in the localization of macrophages.
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影响因子：
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作者：
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发表时间：
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期刊：
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DOI：
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发表时间：
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期刊：
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