Gut Microbiota-brain Axis.
Gut Microbiota-brain Axis.
复制标题
肠道微生物群-脑轴。
DOI：
10.4103/0366-6999.190667
复制
发表时间：
2016-10-05
影响因子：
6.1
通讯作者：
Wang YP
中科院分区：
文献类型：
--
作者：
Wang HX;Wang YP
系统回顾有关肠道菌群-大脑轴的最新信息。截至 2016 年 7 月 18 日发表的所有有关肠道微生物群-脑轴的文章均通过 PubMed、ScienceDirect 和 Web of Science 上的文献检索确定，关键词为“肠道微生物群”、“肠道-脑轴”和“神经科学”。所有关于肠道微生物群和肠脑轴的相关文章都被纳入并经过仔细审查，研究设计没有限制。众所周知，肠道微生物群影响大脑的生理、行为和认知功能，尽管其确切机制尚未完全了解。肠道微生物群-脑轴可能包括肠道微生物群及其代谢产物、肠神经系统、自主神经系统内的交感和副交感分支、神经免疫系统、神经内分泌系统和中枢神经系统。此外，肠道菌群与大脑之间可能存在五种沟通途径，包括肠脑神经网络、神经内分泌-下丘脑-垂体-肾上腺轴、肠道免疫系统、肠道细菌合成的一些神经递质和神经调节剂，以及肠粘膜屏障和血脑屏障等屏障路径。微生物组用于定义肠道微生物群的组成和功能特征，而宏基因组学是表征肠道微生物群的合适技术。肠道菌群-脑轴是指肠道菌群与大脑之间的双向信息网络，这可能在不久的将来为保护大脑提供新的途径。
To systematically review the updated information about the gut microbiota-brain axis. All articles about gut microbiota-brain axis published up to July 18, 2016, were identified through a literature search on PubMed, ScienceDirect, and Web of Science, with the keywords of “gut microbiota”, “gut-brain axis”, and “neuroscience”. All relevant articles on gut microbiota and gut-brain axis were included and carefully reviewed, with no limitation of study design. It is well-recognized that gut microbiota affects the brain's physiological, behavioral, and cognitive functions although its precise mechanism has not yet been fully understood. Gut microbiota-brain axis may include gut microbiota and their metabolic products, enteric nervous system, sympathetic and parasympathetic branches within the autonomic nervous system, neural-immune system, neuroendocrine system, and central nervous system. Moreover, there may be five communication routes between gut microbiota and brain, including the gut-brain's neural network, neuroendocrine-hypothalamic-pituitary-adrenal axis, gut immune system, some neurotransmitters and neural regulators synthesized by gut bacteria, and barrier paths including intestinal mucosal barrier and blood-brain barrier. The microbiome is used to define the composition and functional characteristics of gut microbiota, and metagenomics is an appropriate technique to characterize gut microbiota. Gut microbiota-brain axis refers to a bidirectional information network between the gut microbiota and the brain, which may provide a new way to protect the brain in the near future.
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DOI：
10.1007/978-1-4939-0897-4_6
发表时间：
2014-01-01
期刊：
MICROBIAL ENDOCRINOLOGY: THE MICROBIOTA-GUT-BRAIN AXIS IN HEALTH AND DISEASE
影响因子：
--
作者：
Al Omran, Yasser;Aziz, Qasim
通讯作者：
Aziz, Qasim
影响因子：
3.7
作者：
Bangsgaard Bendtsen KM;Krych L;Sørensen DB;Pang W;Nielsen DS;Josefsen K;Hansen LH;Sørensen SJ;Hansen AK
通讯作者：
Hansen AK
影响因子：
3.7
作者：
Barouei J;Moussavi M;Hodgson DM
通讯作者：
Hodgson DM
影响因子：
64.8
作者：
Claesson, Marcus J.;Jeffery, Ian B.;O'Toole, Paul W.
通讯作者：
O'Toole, Paul W.
DOI：
10.1152/ajpgi.00478.2002
发表时间：
2003-03-01
影响因子：
4.5
作者：
Chang, HY;Mashimo, H;Goyal, RK
通讯作者：
Goyal, RK