Is obesity related to enhanced neural reactivity to visual food cues? A review and meta-analysis.
Is obesity related to enhanced neural reactivity to visual food cues? A review and meta-analysis.
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DOI：
10.1093/scan/nsaa113
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发表时间：
2020-08-12
影响因子：
4.2
通讯作者：
Dagher, Alain
中科院分区：
文献类型：
--
作者：
Morys, Filip;Garcia-Garcia, Isabel;Dagher, Alain
理论研究表明，肥胖与食物暗示的刺激突显增强有关。然而，关于这个话题的行为和神经成像研究的证据喜忧参半。在这项工作中，我们回顾了有关肥胖线索反应性的文献，并对研究肥胖对被动观看食物图片的大脑反应的影响进行了预先注册的荟萃分析。此外，我们还研究了年龄是否会影响肥胖患者对食物暗示的大脑反应。在荟萃分析中，我们包括了13项针对儿童和成人的研究，这些研究调查了儿童和成年人在观看食物和非食物图片时的反应差异(肥胖与瘦)。虽然我们在总体荟萃分析中没有发现显著差异，但我们发现年龄显著影响左侧脑岛和左侧梭形回对食物提示的大脑反应差异。在左侧脑岛，肥胖和精瘦的大脑对食物暗示的反应差异随着年龄的增长而减少，而在左侧梭形回，情况正好相反。我们的结果表明，几乎没有证据表明与肥胖有关的对食物暗示的反应存在差异，而且这种差异可能是由通常不被考虑的其他因素所调节的。
Theoretical work suggests that obesity is related to enhanced incentive salience of food cues. However, evidence from both behavioral and neuroimaging studies on the topic is mixed. In this work, we review the literature on cue reactivity in obesity and perform a preregistered meta-analysis of studies investigating effects of obesity on brain responses to passive food pictures viewing. Further, we examine whether age influences brain responses to food cues in obesity. In the meta-analysis, we included 13 studies of children and adults that investigated group differences (obese vs lean) in responses to food vs non-food pictures viewing. While we found no significant differences in the overall meta-analysis, we show that age significantly influences brain response differences to food cues in the left insula and the left fusiform gyrus. In the left insula, obese vs lean brain differences in response to food cues decreased with age, while in the left fusiform gyrus the pattern was opposite. Our results suggest that there is little evidence for obesity-related differences in responses to food cues and that such differences might be mediated by additional factors that are often not considered.
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