Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors.
Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors.
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具有抑郁样行为的大鼠的热和机械伤害感受阈值增加
DOI：
10.1016/j.brainres.2010.07.023
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发表时间：
2010-09-24
期刊：
影响因子：
2.9
通讯作者：
Luo F
中科院分区：
文献类型：
--
作者：
Shi M;Qi WJ;Gao G;Wang JY;Luo F
临床观察表明，抑郁症患者对实验性疼痛的敏感度低于健康受试者。然而，关于抑郁和疼痛之间的联系的动物研究报道很少。本研究的目的是探讨不可预测的慢性轻度应激(UCMS)诱导的抑郁对大鼠痛觉刺激强度的影响。采用热板法和von Frey法分别测定正常和脊神经结扎(SNL)大鼠的热收缩阈值和机械收缩阈值(PWT)。结果表明，与非抑郁对照组相比，接触UCMS的大鼠表现出明显更高的热痛和机械痛阈值。特别是，SNL组的PWT在UCMS治疗3周后恢复到接近正常的水平，甚至与对照组相当。这些结果强烈表明抑郁症受试者对外部有害刺激的敏感性降低，这与我们之前的发现是一致的。▶不可预测的慢性轻度应激诱导大鼠抑郁行为▶慢性轻度应激提高正常大鼠接触热缩爪阈值▶慢性轻度应激提高正常大鼠机械性缩足阈值▶
Clinical observations suggest that depressed patients were less sensitive to experimental pain than healthy subjects. However, few animal studies are reported concerning the association of depression and pain. The purpose of this study was to investigate the effects of unpredictable chronic mild stress (UCMS) induced depression on the perceived intensity of painful stimulation in rats. We measured the thermal and mechanical paw withdrawal thresholds (PWT) of normal and spinal nerve ligated (SNL) rats using hot plate test and von Frey test, respectively. The results showed that rats exposed to UCMS exhibited significantly higher thermal and mechanical pain thresholds in comparison to the non-depressed controls. In particular, the PWT of the SNL group was restored to nearly normal level after three weeks of UCMS, and even comparable to that of the control group. These results strongly suggest that the depressed subjects have decreased sensitivity to externally applied noxious stimulation, which is consistent with our previous findings. ▶ Unpredictable chronic mild stress (UCMS) induces depressive behaviors in rats ▶ UCMS elevates contact heat paw withdrawal threshold in normal rats ▶ UCMS elevates mechanical paw withdrawal threshold in normal rats ▶ UCMS elevates mechanical paw withdrawal threshold in SNL rats
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影响因子：
2.9
作者：
Gronli, J;Murison, R;Ursin, R
通讯作者：
Ursin, R
影响因子：
3.6
作者：
Gormsen, L;Ribe, AR;Jensen, TS
通讯作者：
Jensen, TS
DOI：
10.3109/10401239309148828
发表时间：
1993-12-01
期刊：
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
影响因子：
--
作者：
Csernansky, J G;Sheline, Y I
通讯作者：
Sheline, Y I
影响因子：
10.6
作者：
ADLER, G;GATTAZ, WF
通讯作者：
GATTAZ, WF
DOI：
10.1017/s1461145708008766
发表时间：
2009-02-01
影响因子：
4.8
作者：
Berrocoso, Esther;Mico, Juan A.
通讯作者：
Mico, Juan A.