DNA-hosted fluorescent gold nanoclusters: sequence-dependent formation
DNA-hosted fluorescent gold nanoclusters: sequence-dependent formation
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DNA 托管荧光金纳米团簇：序列依赖性形成
DOI：
10.1088/0957-4484/24/1/015503
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发表时间：
2013-01
期刊：
影响因子：
3.5
通讯作者：
Liu Lingling
中科院分区：
文献类型：
--
作者：
Liu Guiying;Shao Yong;Wu Fei;Xu Shujuan;Peng Jian;Liu Lingling
多种DNA被用作宿主，以研究水溶液中荧光金纳米团簇（Au NCs）的序列依赖性形成。通过对具有原始茎段和不同环序列的发夹DNA（HP - DNAs）进行比较，我们发现……
Various DNAs were employed as hosts to investigate the sequence-dependent formation of fluorescent Au nanoclusters (Au NCs) in aqueous solution. By comparison among hairpin DNAs (HP-DNAs) with a pristine stem segment and varied loop sequences, we found that the emission behavior of the HP-DNA-hosted Au NCs is dependent on the loop sequences. The most efficient host to produce fluorescent Au NCs is the cytosine loop. However, relative to the cytosine and guanine loops, the loop composed of thymine as well as adenine produces Au NCs with a much weaker emission. Additionally, the emission behavior of Au NCs hosted by the single-stranded DNAs (ss-DNAs) with an identical base composition to the corresponding HP-DNAs still exhibits a cytosine-rich dependence. The fully matched DNAs seem to be less efficient than the corresponding loop and ss-DNA structures. Furthermore, the emission properties of HP-DNA-hosted Au NCs can be modulated by the loop length. The sequence-dependent formation of fluorescent Au NCs is believed to be caused by differences in binding nucleophilicity of the DNA heterocyclic nitrogen and exocyclic keto groups to the hydrolyzed Au(III) species. This work demonstrates the role of sequence in producing Au NCs that could serve as promising fluorescent nanoprobes in biosensing and DNA-hosted Au nanomaterials.
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影响因子：
29.4
作者：
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通讯作者：
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