Canine parvovirus--a review of epidemiological and diagnostic aspects, with emphasis on type 2c.
Canine parvovirus--a review of epidemiological and diagnostic aspects, with emphasis on type 2c.
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DOI：
10.1016/j.vetmic.2011.09.007
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发表时间：
2012-02-24
影响因子：
3.3
通讯作者：
Buonavoglia C
中科院分区：
文献类型：
--
作者：
Decaro N;Buonavoglia C
2 型犬细小病毒 (CPV-2) 于 20 世纪 70 年代末出现，在全世界的狗舍和收容所中引起严重的动物流行。 CPV-2出现后不久，经历了基因进化，连续产生了两种抗原变体：CPV-2a和CPV-2b，并逐渐取代了原始类型。 2000年，意大利检测到一种新的抗原变种CPV-2c，并迅速传播到多个国家。与原始型CPV-2相比，抗原变体对狗的致病性增强，宿主范围扩大，能够感染猫并引起疾病。流行病学调查表明，最新型 CPV-2c 正在不同地理区域流行，并且通常与成年犬和已完成疫苗接种方案的犬的严重疾病有关。然而，CPV 疫苗接种失败的主要原因是母源免疫力的干扰。传统方法对 CPV 感染的诊断已被证明敏感性较差，尤其是在感染晚期。已经开发出基于分子方法的新诊断方法，用于灵敏检测临床样本中的 CPV 并快速表征病毒类型。持续监测将有助于评估是否确实需要更新当前可用的疫苗和诊断测试。
Canine parvovirus type 2 (CPV-2) emerged in late 1970s causing severe epizootics in kennels and dog shelters worldwide. Soon after its emergence, CPV-2 underwent genetic evolution giving rise consecutively to two antigenic variants, CPV-2a and CPV-2b that replaced progressively the original type. In 2000, a new antigenic variant, CPV-2c, was detected in Italy and rapidly spread to several countries. In comparison to the original type CPV-2, the antigenic variants display increased pathogenicity in dogs and extended host range, being able to infect and cause disease in cats. Epidemiological survey indicate that the newest type CPV-2c is becoming prevalent in different geographic regions and is often associated to severe disease in adult dogs and also in dogs that have completed the vaccination protocols. However, the primary cause of failure of CPV vaccination is interference by maternally derived immunity. Diagnosis of CPV infection by traditional methods has been shown to be poorly sensitive, especially in the late stages of infections. New diagnostic approaches based on molecular methods have been developed for sensitive detection of CPV in clinical samples and rapid characterisation of the viral type. Continuous surveillance will help assess whether there is a real need to update currently available vaccines and diagnostic tests.
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影响因子：
3.8
作者：
Decaro, N.;Desario, C.;Buonavoglia, C.
通讯作者：
Buonavoglia, C.
影响因子：
3.1
作者：
Decaro, Nicola;Martella, Vito;Buonavoglia, Canio
通讯作者：
Buonavoglia, Canio
影响因子：
1.7
作者：
Decaro, Nicola;Desario, Costantina;Buonavoglia, Canio
通讯作者：
Buonavoglia, Canio
DOI：
10.1111/j.1439-0450.2005.00868.x
发表时间：
2005-09-01
期刊：
JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH
影响因子：
--
作者：
Carmichael, LE
通讯作者：
Carmichael, LE
DOI：
10.1111/j.1439-0450.2005.00869.x
发表时间：
2005-09-01
期刊：
JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH
影响因子：
--
作者：
Decaro, N;Elia, G;Buonavoglia, C
通讯作者：
Buonavoglia, C